Pseudomonas aeruginosa PAO1, PA1813

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1813
Name
Synonym: gloB
Replicon chromosome
Genomic location 1971317 - 1972093 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250504.1
GI 15597010
Affymetrix PA1813_at
Entrez 878377
GenBank AAG05202.1
INSDC AAG05202.1
NCBI Locus Tag PA1813
protein_id(GenBank) gb|AAG05202.1|AE004608_1|gnl|PseudoCAP|PA1813
TIGR NTL03PA01814
UniParc UPI00000C54AC
UniProtKB Acc Q9I2T1
UniProtKB ID GLO2_PSEAE
UniRef100 UniRef100_Q9I2T1
UniRef50 UniRef50_Q4KBH9
UniRef90 UniRef90_Q9I2T1

Product

Feature Type CDS
Coding Frame 1
Product Name
probable hydroxyacylglutathione hydrolase
Product Name Confidence: Class 3
Synonyms probable glyoxalase II
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.99
Kyte-Doolittle Hydrophobicity Value -0.251
Molecular Weight (kDa) 28.9
Isoelectric Point (pI) 6.32

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
8EWO HYDROLASE 10/24/22 Crystal structure of putative glyoxylase II from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 2.47 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 547 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003585 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1813

Human Homologs

Ensembl 110, assembly GRCh38.p14
hydroxyacylglutathione hydrolase [Source:HGNC Symbol;Acc:HGNC:4805]
E-value: 2.1e-41
Percent Identity: 38.0
Ensembl 110, assembly GRCh38.p14
hydroxyacylglutathione hydrolase [Source:HGNC Symbol;Acc:HGNC:4805]
E-value: 2.1e-41
Percent Identity: 38.0

References

Molecular characterization of glyoxalase II from Arabidopsis thaliana.
Maiti MK, Krishnasamy S, Owen HA, Makaroff CA
Plant Mol Biol 1997 Nov;35(4):471-81
PubMed ID: 9349270