Pseudomonas aeruginosa PAO1, PA3112 (accD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3112
Name
accD
Synonym: dedB
Replicon chromosome
Genomic location 3492701 - 3493573 (- strand)

Cross-References

RefSeq NP_251802.1
GI 15598308
Affymetrix PA3112_accD_at
DNASU PaCD00007368
Entrez 877680
GenBank AAG06500.1
INSDC AAG06500.1
NCBI Locus Tag PA3112
protein_id(GenBank) gb|AAG06500.1|AE004735_7|gnl|PseudoCAP|PA3112
TIGR NTL03PA03112
UniParc UPI00000C60B4
UniProtKB Acc Q9HZA7
UniProtKB ID ACCD_PSEAE
UniRef100 UniRef100_Q02PS5
UniRef50 UniRef50_Q8FFH5
UniRef90 UniRef90_Q02PS5

Product

Feature Type CDS
Coding Frame 1
Product Name
acetyl-CoA carboxylase beta subunit
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) 0.24
Kyte-Doolittle Hydrophobicity Value -0.053
Molecular Weight (kDa) 31.8
Isoelectric Point (pI) 7.08

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 596 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002486 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3112
Search term: accD

Human Homologs

References

Growth rate regulation of Escherichia coli acetyl coenzyme A carboxylase, which catalyzes the first committed step of lipid biosynthesis.
Li SJ, Cronan JE Jr
J Bacteriol 1993 Jan;175(2):332-40
PubMed ID: 7678242
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994