Pseudomonas aeruginosa PAO1, PA3437 (folM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3437
Name
folM
Synonym: ydgB
Replicon chromosome
Genomic location 3845053 - 3845757 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252127.1
GI 15598633
Affymetrix PA3437_at
DNASU PaCD00007512
Entrez 878764
GenBank AAG06825.1
INSDC AAG06825.1
NCBI Locus Tag PA3437
protein_id(GenBank) gb|AAG06825.1|AE004764_11|gnl|PseudoCAP|PA3437
TIGR NTL03PA03437
UniParc UPI00000C5A0F
UniProtKB Acc Q9HYG9
UniProtKB ID Q9HYG9_PSEAE
UniRef100 UniRef100_W0YWA4
UniRef50 UniRef50_Q48MN0
UniRef90 UniRef90_Q02QS5

Product

Feature Type CDS
Coding Frame 1
Product Name
dihydromonapterin reductase, FolM
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 0.07
Kyte-Doolittle Hydrophobicity Value 0.001
Molecular Weight (kDa) 25.4
Isoelectric Point (pI) 7.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 606 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002199 (490 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3437
Search term: folM

Human Homologs

References

FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa.
Pribat A, Blaby IK, Lara-Núñez A, Gregory JF 3rd, de Crécy-Lagard V, Hanson AD
J Bacteriol 2010 Jan;192(2):475-82
PubMed ID: 19897652