Pseudomonas aeruginosa PAO1, PA3737 (dsbC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3737
Name
dsbC
Replicon chromosome
Genomic location 4189761 - 4190489 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252426.1
GI 15598932
Affymetrix PA3737_dsbC_at
Entrez 880330
GenBank AAG07124.1
INSDC AAG07124.1
NCBI Locus Tag PA3737
protein_id(GenBank) gb|AAG07124.1|AE004793_1|gnl|PseudoCAP|PA3737
TIGR NTL03PA03737
UniParc UPI00000D4251
UniProtKB Acc G3XD17
UniProtKB ID G3XD17_PSEAE
UniRef100 UniRef100_W0YU45
UniRef50 UniRef50_Q4KHQ0
UniRef90 UniRef90_A6V131

Product

Feature Type CDS
Coding Frame 1
Product Name
thiol:disulfide interchange protein DsbC
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 4.35
Kyte-Doolittle Hydrophobicity Value -0.198
Molecular Weight (kDa) 26.1
Isoelectric Point (pI) 8.84

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 2
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 153 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001945 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3737
Search term: dsbC

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Structural and functional characterization of DsbC, a protein involved in disulfide bond formation in Escherichia coli.
Zapun A, Missiakas D, Raina S, Creighton TE
Biochemistry 1995 Apr 18;34(15):5075-89
PubMed ID: 7536035
Making and breaking disulfide bonds.
Raina S, Missiakas D
Annu Rev Microbiol 1997;51:179-202
PubMed ID: 9343348