Pseudomonas aeruginosa PAO1, PA4407 (ftsZ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4407
Name
ftsZ
Replicon chromosome
Genomic location 4939300 - 4940484 (- strand)

Cross-References

RefSeq NP_253097.1
GI 15599603
Affymetrix PA4407_ftsZ_at
Entrez 881296
GenBank AAG07795.1
INSDC AAG07795.1
NCBI Locus Tag PA4407
protein_id(GenBank) gb|AAG07795.1|AE004856_6|gnl|PseudoCAP|PA4407
TIGR NTL03PA04408
UniParc UPI000012AD2E
UniProtKB Acc P47204
UniProtKB ID FTSZ_PSEAE
UniRef100 UniRef100_P47204
UniRef50 UniRef50_P47204
UniRef90 UniRef90_P47204

Product

Feature Type CDS
Coding Frame 1
Product Name
cell division protein FtsZ
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -12.08
Kyte-Doolittle Hydrophobicity Value 0.016
Molecular Weight (kDa) 41.2
Isoelectric Point (pI) 4.66

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2VAW CELL CYCLE 09/04/07 FtsZ Pseudomonas aeruginosa GDP PSEUDOMONAS AERUGINOSA 2.9 X-RAY DIFFRACTION 100.0
1OFU BACTERIAL CELL DIVISION INHIBITOR 04/21/03 Crystal structure of SulA:FtsZ from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 2.1 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 622 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003997 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4407
Search term: ftsZ

Human Homologs

References

Structure and expression of the cell division genes ftsQ, ftsA and ftsZ.
Yi QM, Rockenbach S, Ward JE Jr, Lutkenhaus J
J Mol Biol 1985 Aug 5;184(3):399-412
PubMed ID: 2995680
Preferential cytoplasmic location of FtsZ, a protein essential for Escherichia coli septation.
Pla J, Sánchez M, Palacios P, Vicente M, Aldea M
Mol Microbiol 1991 Jul;5(7):1681-6
PubMed ID: 1943703
Escherichia coli cell-division gene ftsZ encodes a novel GTP-binding protein.
RayChaudhuri D, Park JT
Nature 1992 Sep 17;359(6392):251-4
PubMed ID: 1528267
The FtsZ protein of Bacillus subtilis is localized at the division site and has GTPase activity that is dependent upon FtsZ concentration.
Wang X, Lutkenhaus J
Mol Microbiol 1993 Aug;9(3):435-42
PubMed ID: 8412693
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994