Pseudomonas aeruginosa PAO1, PA4841

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4841
Name
Replicon chromosome
Genomic location 5434116 - 5434652 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentPA4841 mutant is susceptible to killing by H2O2 [PMID:32419387]

Cross-References

RefSeq NP_253528.1
GI 15600034
Affymetrix PA4841_at
DNASU PaCD00008102
Entrez 879630
GenBank AAG08226.1
INSDC AAG08226.1
NCBI Locus Tag PA4841
protein_id(GenBank) gb|AAG08226.1|AE004897_4|gnl|PseudoCAP|PA4841
TIGR NTL03PA04842
UniParc UPI000013A5F4
UniProtKB Acc Q9HUW9
UniProtKB ID Y4841_PSEAE
UniRef100 UniRef100_Q9HUW9
UniRef50 UniRef50_Q9HUW9
UniRef90 UniRef90_Q9HUW9

Product

Feature Type CDS
Coding Frame 1
Product Name
NUDIX hydrolase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -10.61
Kyte-Doolittle Hydrophobicity Value -0.163
Molecular Weight (kDa) 19.7
Isoelectric Point (pI) 4.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 181 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004471 (506 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4841
Search term: NUDIX hydrolase

Human Homologs

References

Individual Nudix hydrolases affect diverse features of Pseudomonas aeruginosa.
Drabinska J, Ziecina M, Modzelan M, Jagura-Burdzy G, Kraszewska E
Microbiologyopen 2020 Aug;9(8):e1052
PubMed ID: 32419387