Pseudomonas aeruginosa PAO1, PA4988 (waaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4988
Name
waaA
Synonym: kdtA
Replicon chromosome
Genomic location 5603821 - 5605098 (- strand)

Cross-References

RefSeq NP_253675.1
GI 15600181
Affymetrix PA4988_waaA_at
Entrez 880145
GenBank AAG08373.1
INSDC AAG08373.1
NCBI Locus Tag PA4988
protein_id(GenBank) gb|AAG08373.1|AE004911_8|gnl|PseudoCAP|PA4988
TIGR NTL03PA04989
UniParc UPI00000C5EB1
UniProtKB Acc Q9HUH7
UniProtKB ID Q9HUH7_PSEAE
UniRef100 UniRef100_Q9HUH7
UniRef50 UniRef50_S6C029
UniRef90 UniRef90_Q9HUH7

Product

Feature Type CDS
Coding Frame 1
Product Name
3-deoxy-D-manno-octulosonic-acid (KDO) transferase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 7.72
Kyte-Doolittle Hydrophobicity Value 0.102
Molecular Weight (kDa) 46.5
Isoelectric Point (pI) 8.83

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 346 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004599 (531 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4988
Search term: waaA

Human Homologs

References

Inhibition of lipopolysaccharide biosynthesis and cell growth following inactivation of the kdtA gene in Escherichia coli.
Belunis CJ, Clementz T, Carty SM, Raetz CR
J Biol Chem 1995 Nov 17;270(46):27646-52
PubMed ID: 7499229