Pseudomonas aeruginosa PAO1, PA0685 (hxcQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0685
Name
hxcQ
Replicon chromosome
Genomic location 741925 - 744336 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 5 transposon mutants in orthologs
CommentHxc proteins are involved with alkaline phosphatase secretion. Belongs to the GspD family (general secretory pathway).

Cross-References

RefSeq NP_249376.1
GI 15595882
Affymetrix PA0685_at
Entrez 880813
GenBank AAG04074.1
INSDC AAG04074.1
NCBI Locus Tag PA0685
protein_id(GenBank) gb|AAG04074.1|AE004503_12|gnl|PseudoCAP|PA0685
TIGR NTL03PA00686
UniParc UPI00000C50FE
UniProtKB Acc Q9I5P0
UniProtKB ID Q9I5P0_PSEAE
UniRef100 UniRef100_V6AK45
UniRef50 UniRef50_B2FUI1
UniRef90 UniRef90_A6VAT1

Product

Feature Type CDS
Coding Frame 1
Product Name
HxcQ
Product Name Confidence: Class 1
Synonyms probable type II secretion system protein
Evidence for Translation
Charge (pH 7) -0.03
Kyte-Doolittle Hydrophobicity Value -0.178
Molecular Weight (kDa) 83.9
Isoelectric Point (pI) 6.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Outer Membrane Class 2
Outer Membrane Class 1
heterologous protein expression evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 337 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000664 (1798 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0685
Search term: hxcQ
Search term: HxcQ

Human Homologs

References

A novel type II secretion system in Pseudomonas aeruginosa.
Ball G, Durand E, Lazdunski A, Filloux A
Mol Microbiol 2002 Jan;43(2):475-85
PubMed ID: 11985723
Subcellular location of XpsD, a protein required for extracellular protein secretion by Xanthomonas campestris pv. campestris.
Hu NT, Hung MN, Liao CT, Lin MH
Microbiology (Reading) 1995 Jun;141 ( Pt 6):1395-1406
PubMed ID: 7670641
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295