Pseudomonas aeruginosa PAO1, PA0687 (hxcS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0687
Name
hxcS
Replicon chromosome
Genomic location 745742 - 746956 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
CommentBelongs to the GspF family (general secretory pathway). The hxc gene cluster is under phosphate control. The Hxc proteins are involved in alkaline phosphatase secretion.

Cross-References

RefSeq NP_249378.1
GI 15595884
Affymetrix PA0687_at
Entrez 880805
GenBank AAG04076.1
INSDC AAG04076.1
NCBI Locus Tag PA0687
protein_id(GenBank) gb|AAG04076.1|AE004503_14|gnl|PseudoCAP|PA0687
TIGR NTL03PA00688
UniParc UPI00000C5100
UniProtKB Acc Q9I5N8
UniProtKB ID Q9I5N8_PSEAE
UniRef100 UniRef100_K1DT35
UniRef50 UniRef50_D5CMQ1
UniRef90 UniRef90_A6VAS9

Product

Feature Type CDS
Coding Frame 1
Product Name
HxcS
Product Name Confidence: Class 1
Synonyms probable type II secretion system protein
Evidence for Translation
Charge (pH 7) 4.67
Kyte-Doolittle Hydrophobicity Value 0.240
Molecular Weight (kDa) 43.4
Isoelectric Point (pI) 9.42

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 400 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000666 (814 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0687
Search term: hxcS
Search term: HxcS

Human Homologs

References

A novel type II secretion system in Pseudomonas aeruginosa.
Ball G, Durand E, Lazdunski A, Filloux A
Mol Microbiol 2002 Jan;43(2):475-85
PubMed ID: 11985723
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Protein secretion in Pseudomonas aeruginosa: characterization of seven xcp genes and processing of secretory apparatus components by prepilin peptidase.
Bally M, Filloux A, Akrim M, Ball G, Lazdunski A, Tommassen J
Mol Microbiol 1992 May;6(9):1121-31
PubMed ID: 1588814