Pseudomonas aeruginosa PAO1, PA2515 (xylL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2515
Name
xylL
Replicon chromosome
Genomic location 2832369 - 2833130 (- strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_251205.1
GI 15597711
Affymetrix PA2515_xylL_at
Entrez 880342
GenBank AAG05903.1
INSDC AAG05903.1
NCBI Locus Tag PA2515
protein_id(GenBank) gb|AAG05903.1|AE004678_9|gnl|PseudoCAP|PA2515
TIGR NTL03PA02515
UniParc UPI00000C5715
UniProtKB Acc Q9I0W7
UniProtKB ID Q9I0W7_PSEAE
UniRef100 UniRef100_Q9I0W7
UniRef50 UniRef50_P07772
UniRef90 UniRef90_S0II28

Product

Feature Type CDS
Coding Frame 1
Product Name
cis-1,2-dihydroxycyclohexa-3,4-diene carboxylate dehydrogenase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -3.70
Kyte-Doolittle Hydrophobicity Value -0.063
Molecular Weight (kDa) 27.2
Isoelectric Point (pI) 5.19

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 651 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003049 (436 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2515
Search term: xylL

Human Homologs

Ensembl 110, assembly GRCh38.p14
15-hydroxyprostaglandin dehydrogenase [Source:HGNC Symbol;Acc:HGNC:5154]
E-value: 2.0e-12
Percent Identity: 30.2

References

cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal benD gene are members of the short-chain alcohol dehydrogenase superfamily.
Neidle E, Hartnett C, Ornston LN, Bairoch A, Rekik M, Harayama S
Eur J Biochem 1992 Feb 15;204(1):113-20
PubMed ID: 1740120