Pseudomonas aeruginosa PAO1, PA2554

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2554
Name
Replicon chromosome
Genomic location 2886570 - 2887337 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251244.1
GI 15597750
Affymetrix PA2554_at
Entrez 882742
GenBank AAG05942.1
INSDC AAG05942.1
NCBI Locus Tag PA2554
protein_id(GenBank) gb|AAG05942.1|AE004683_6|gnl|PseudoCAP|PA2554
TIGR NTL03PA02554
UniParc UPI00000C5737
UniProtKB Acc Q9I0T0
UniProtKB ID Q9I0T0_PSEAE
UniRef100 UniRef100_W0YQI4
UniRef50 UniRef50_V4YP29
UniRef90 UniRef90_A6V4Q7

Product

Feature Type CDS
Coding Frame 1
Product Name
probable short-chain dehydrogenase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.55
Kyte-Doolittle Hydrophobicity Value 0.199
Molecular Weight (kDa) 26.4
Isoelectric Point (pI) 6.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 650 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003017 (954 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2554

Human Homologs

Ensembl 110, assembly GRCh38.p14
hydroxysteroid 17-beta dehydrogenase 10 [Source:HGNC Symbol;Acc:HGNC:4800]
E-value: 2.2e-72
Percent Identity: 57.5

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295