Pseudomonas aeruginosa PAO1, PA2622 (cspD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2622
Name
cspD
Replicon chromosome
Genomic location 2965201 - 2965473 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251312.1
GI 15597818
Affymetrix PA2622_cspD_at
Entrez 882328
GenBank AAG06010.1
INSDC AAG06010.1
NCBI Locus Tag PA2622
protein_id(GenBank) gb|AAG06010.1|AE004691_1|gnl|PseudoCAP|PA2622
TIGR NTL03PA02622
UniParc UPI00000C5770
UniProtKB Acc Q9I0L6
UniProtKB ID Q9I0L6_PSEAE
UniRef100 UniRef100_W0YTN8
UniRef50 UniRef50_A6V4G4
UniRef90 UniRef90_A6V4G4

Product

Feature Type CDS
Coding Frame 1
Product Name
cold-shock protein CspD
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.54
Kyte-Doolittle Hydrophobicity Value -0.286
Molecular Weight (kDa) 9.6
Isoelectric Point (pI) 5.63

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 497 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002930 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2622
Search term: cspD

Human Homologs

Ensembl 110, assembly GRCh38.p14
lin-28 homolog B [Source:HGNC Symbol;Acc:HGNC:32207]
E-value: 5.2e-08
Percent Identity: 37.1
Ensembl 110, assembly GRCh38.p14
lin-28 homolog B [Source:HGNC Symbol;Acc:HGNC:32207]
E-value: 5.2e-08
Percent Identity: 37.1
Ensembl 110, assembly GRCh38.p14
lin-28 homolog B [Source:HGNC Symbol;Acc:HGNC:32207]
E-value: 5.2e-08
Percent Identity: 37.1

References

The ATP-dependent Clp protease of Escherichia coli. Sequence of clpA and identification of a Clp-specific substrate.
Gottesman S, Clark WP, Maurizi MR
J Biol Chem 1990 May 15;265(14):7886-93
PubMed ID: 2186030