Pseudomonas aeruginosa PAO1, PA3466

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3466
Name
Synonym: srmB
Replicon chromosome
Genomic location 3878033 - 3879373 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_252156.1
GI 15598662
Affymetrix PA3466_at
Entrez 877976
GenBank AAG06854.1
INSDC AAG06854.1
NCBI Locus Tag PA3466
protein_id(GenBank) gb|AAG06854.1|AE004767_5|gnl|PseudoCAP|PA3466
TIGR NTL03PA03466
UniParc UPI00000C5A28
UniProtKB Acc Q9HYE0
UniProtKB ID Q9HYE0_PSEAE
UniRef100 UniRef100_S0IPA7
UniRef50 UniRef50_A0A098FQD5
UniRef90 UniRef90_B7UWL4

Product

Feature Type CDS
Coding Frame 1
Product Name
probable ATP-dependent RNA helicase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 21.09
Kyte-Doolittle Hydrophobicity Value -0.308
Molecular Weight (kDa) 49.0
Isoelectric Point (pI) 10.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 646 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002174 (538 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3466

Human Homologs

Ensembl 110, assembly GRCh38.p14
DEAD-box helicase 42 [Source:HGNC Symbol;Acc:HGNC:18676]
E-value: 2.9e-59
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
DEAD-box helicase 42 [Source:HGNC Symbol;Acc:HGNC:18676]
E-value: 2.9e-59
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
DEAD-box helicase 42 [Source:HGNC Symbol;Acc:HGNC:18676]
E-value: 2.9e-59
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
DEAD-box helicase 42 [Source:HGNC Symbol;Acc:HGNC:18676]
E-value: 2.9e-59
Percent Identity: 37.3

References

An eIF-4A-like protein is a suppressor of an Escherichia coli mutant defective in 50S ribosomal subunit assembly.
Nishi K, Morel-Deville F, Hershey JW, Leighton T, Schnier J
Nature 1988 Dec 1;336(6198):496-8
PubMed ID: 2461520