Pseudomonas aeruginosa PAO1, PA4293 (pprA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4293
Name
pprA
Synonym: pprA
Replicon chromosome
Genomic location 4816580 - 4819348 (- strand)
Transposon Mutants 6 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_252983.1
GI 15599489
Affymetrix PA4293_at
Entrez 881624
GenBank AAG07681.1
INSDC AAG07681.1
NCBI Locus Tag PA4293
protein_id(GenBank) gb|AAG07681.1|AE004845_7|gnl|PseudoCAP|PA4293
TIGR NTL03PA04294
UniParc UPI00000C5C9E
UniProtKB Acc Q9HWA7
UniProtKB ID Q9HWA7_PSEAE
UniRef100 UniRef100_Q9HWA7
UniRef50 UniRef50_Q9HWA7
UniRef90 UniRef90_Q9HWA7

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component sensor PprA
Product Name Confidence: Class 1
Synonyms two-component sensor PprA
Evidence for Translation
Charge (pH 7) -13.93
Kyte-Doolittle Hydrophobicity Value -0.285
Molecular Weight (kDa) 102.1
Isoelectric Point (pI) 5.92

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 600 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001509 (868 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4293
Search term: pprA

Human Homologs

References

Regulation of membrane permeability by a two-component regulatory system in Pseudomonas aeruginosa.
Wang Y, Ha U, Zeng L, Jin S
Antimicrob Agents Chemother 2003 Jan;47(1):95-101
PubMed ID: 12499175
A novel response-regulator is able to suppress the nodulation defect of a Bradyrhizobium japonicum nodW mutant.
Grob P, Michel P, Hennecke H, Göttfert M
Mol Gen Genet 1993 Dec;241(5-6):531-41
PubMed ID: 8264528