Pseudomonas aeruginosa PAO1, PA4409 (ftsQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4409
Name
ftsQ
Replicon chromosome
Genomic location 4941810 - 4942673 (- strand)

Cross-References

RefSeq NP_253099.1
GI 15599605
Affymetrix PA4409_ftsQ_at
DNASU PaCD00007910
Entrez 881322
GenBank AAG07797.1
INSDC CEI77491.1
NCBI Locus Tag PA4409
protein_id(GenBank) gb|AAG07797.1|AE004856_8|gnl|PseudoCAP|PA4409
TIGR NTL03PA04410
UniParc UPI00000C4EDE
UniProtKB Acc Q9LCT5
UniProtKB ID Q9LCT5_PSEAI
UniRef100 UniRef100_G3XDA7
UniRef50 UniRef50_G3XDA7
UniRef90 UniRef90_G3XDA7

Product

Feature Type CDS
Coding Frame 1
Product Name
cell division protein FtsQ
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 11.19
Kyte-Doolittle Hydrophobicity Value -0.206
Molecular Weight (kDa) 32.2
Isoelectric Point (pI) 10.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
8BH1 MEMBRANE PROTEIN 10/28/22 Core divisome complex FtsWIQBL from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 3.8 ELECTRON MICROSCOPY 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 168 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003999 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4409
Search term: ftsQ

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
DNA sequence and transcriptional organization of essential cell division genes ftsQ and ftsA of Escherichia coli: evidence for overlapping transcriptional units.
Robinson AC, Kenan DJ, Hatfull GF, Sullivan NF, Spiegelberg R, Donachie WD
J Bacteriol 1984 Nov;160(2):546-55
PubMed ID: 6094474
Structure and expression of the cell division genes ftsQ, ftsA and ftsZ.
Yi QM, Rockenbach S, Ward JE Jr, Lutkenhaus J
J Mol Biol 1985 Aug 5;184(3):399-412
PubMed ID: 2995680
Further evidence for overlapping transcriptional units in an Escherichia coli cell envelope-cell division gene cluster: DNA sequence and transcriptional organization of the ddl ftsQ region.
Robinson AC, Kenan DJ, Sweeney J, Donachie WD
J Bacteriol 1986 Sep;167(3):809-17
PubMed ID: 3528126
Localization of FtsI (PBP3) to the septal ring requires its membrane anchor, the Z ring, FtsA, FtsQ, and FtsL.
Weiss DS, Chen JC, Ghigo JM, Boyd D, Beckwith J
J Bacteriol 1999 Jan;181(2):508-20
PubMed ID: 9882665