Pseudomonas aeruginosa PAO1, PA4809 (fdhE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4809
Name
fdhE
Replicon chromosome
Genomic location 5395930 - 5396859 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253497.1
GI 15600003
Affymetrix PA4809_fdhE_at
Entrez 880170
GenBank AAG08195.1
INSDC AAG08195.1
NCBI Locus Tag PA4809
protein_id(GenBank) gb|AAG08195.1|AE004894_1|gnl|PseudoCAP|PA4809
TIGR NTL03PA04810
UniParc UPI000012A5F1
UniProtKB Acc Q9HV00
UniProtKB ID FDHE_PSEAE
UniRef100 UniRef100_Q9HV00
UniRef50 UniRef50_Q9HV00
UniRef90 UniRef90_Q9HV00

Product

Feature Type CDS
Coding Frame 1
Product Name
FdhE protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.90
Kyte-Doolittle Hydrophobicity Value -0.120
Molecular Weight (kDa) 33.8
Isoelectric Point (pI) 5.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2FIY Structural genomics, unknown function 12/30/05 The crystal structure of the FdhE protein from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 99 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004445 (425 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4809
Search term: fdhE
Search term: FdhE protein

Human Homologs

References

Mutants of Escherichia coli specifically deficient in respiratory formate dehydrogenase activity.
Mandrand-Berthelot MA, Couchoux-Luthaud G, Santini CL, Giordano G
J Gen Microbiol 1988 Dec;134(12):3129-39
PubMed ID: 3077634
Identification and expression of the Escherichia coli fdhD and fdhE genes, which are involved in the formation of respiratory formate dehydrogenase.
Schlindwein C, Giordano G, Santini CL, Mandrand MA
J Bacteriol 1990 Oct;172(10):6112-21
PubMed ID: 2170340