Pseudomonas aeruginosa PAO1, PA4829 (lpd3)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4829
Name
lpd3
Replicon chromosome
Genomic location 5420323 - 5421726 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253516.1
GI 15600022
Affymetrix PA4829_lpd3_at
Entrez 882254
GenBank AAG08214.1
INSDC AAG08214.1
NCBI Locus Tag PA4829
protein_id(GenBank) gb|AAG08214.1|AE004896_4|gnl|PseudoCAP|PA4829
TIGR NTL03PA04830
UniParc UPI00000C5E2A
UniProtKB Acc Q9HUY1
UniProtKB ID DLDH3_PSEAE
UniRef100 UniRef100_Q9HUY1
UniRef50 UniRef50_Q9HUY1
UniRef90 UniRef90_Q9HUY1

Product

Feature Type CDS
Coding Frame 1
Product Name
dihydrolipoamide dehydrogenase 3
Product Name Confidence: Class 2
Synonyms LPD-3
Evidence for Translation
Charge (pH 7) -7.54
Kyte-Doolittle Hydrophobicity Value -0.021
Molecular Weight (kDa) 49.7
Isoelectric Point (pI) 5.82

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 639 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004461 (398 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4829
Search term: lpd3

Human Homologs

Ensembl 110, assembly GRCh38.p14
dihydrolipoamide dehydrogenase [Source:HGNC Symbol;Acc:HGNC:2898]
E-value: 6.8e-128
Percent Identity: 51.2
Ensembl 110, assembly GRCh38.p14
dihydrolipoamide dehydrogenase [Source:HGNC Symbol;Acc:HGNC:2898]
E-value: 6.8e-128
Percent Identity: 51.2

References

Isolation of a third lipoamide dehydrogenase from Pseudomonas putida.
Burns G, Sykes PJ, Hatter K, Sokatch JR
J Bacteriol 1989 Feb;171(2):665-8
PubMed ID: 2914869
Cloning, sequence and transcriptional analysis of the structural gene for LPD-3, the third lipoamide dehydrogenase of Pseudomonas putida.
Palmer JA, Madhusudhan KT, Hatter K, Sokatch JR
Eur J Biochem 1991 Dec 5;202(2):231-40
PubMed ID: 1722146