Pseudomonas aeruginosa PAO1, PA4899

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4899
Name
Replicon chromosome
Genomic location 5495821 - 5497290 (- strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
Commenttranscription induced by vanillate

Cross-References

RefSeq NP_253586.1
GI 15600092
Affymetrix PA4899_at
Entrez 879749
GenBank AAG08284.1
INSDC AAG08284.1
NCBI Locus Tag PA4899
protein_id(GenBank) gb|AAG08284.1|AE004903_2|gnl|PseudoCAP|PA4899
TIGR NTL03PA04900
UniParc UPI00000C5E69
UniProtKB Acc Q9HUR4
UniProtKB ID Q9HUR4_PSEAE
UniRef100 UniRef100_W0YVR8
UniRef50 UniRef50_Q4KB05
UniRef90 UniRef90_Z2DPE3

Product

Feature Type CDS
Coding Frame 1
Product Name
probable aldehyde dehydrogenase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -8.90
Kyte-Doolittle Hydrophobicity Value -0.055
Molecular Weight (kDa) 52.7
Isoelectric Point (pI) 5.78

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 600 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004522 (427 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4899

Human Homologs

Ensembl 110, assembly GRCh38.p14
aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol;Acc:HGNC:402]
E-value: 5.4e-75
Percent Identity: 36.8

References

Comparison of benzyl alcohol dehydrogenases and benzaldehyde dehydrogenases from the benzyl alcohol and mandelate pathways in Acinetobacter calcoaceticus and from the TOL-plasmid-encoded toluene pathway in Pseudomonas putida. N-terminal amino acid sequences, amino acid compositions and immunological cross-reactions.
Chalmers RM, Keen JN, Fewson CA
Biochem J 1991 Jan 1;273(Pt 1)(Pt 1):99-107
PubMed ID: 1989592