Pseudomonas aeruginosa PAO1, PA5361 (phoR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5361
Name
phoR
Replicon chromosome
Genomic location 6027542 - 6028873 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254048.1
GI 15600554
Affymetrix PA5361_phoR_at
Entrez 878511
GenBank AAG08746.1
INSDC AAG08746.1
NCBI Locus Tag PA5361
protein_id(GenBank) gb|AAG08746.1|AE004948_2|gnl|PseudoCAP|PA5361
TIGR NTL03PA05362
UniParc UPI00001319CE
UniProtKB Acc P23621
UniProtKB ID PHOR_PSEAE
UniRef100 UniRef100_P23621
UniRef50 UniRef50_P23621
UniRef90 UniRef90_P23621

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component sensor PhoR
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 2.83
Kyte-Doolittle Hydrophobicity Value -0.334
Molecular Weight (kDa) 50.1
Isoelectric Point (pI) 7.58

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 619 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004926 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5361
Search term: phoR

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Nucleotide sequence of the phoR gene, a regulatory gene for the phosphate regulon of Escherichia coli.
Makino K, Shinagawa H, Amemura M, Nakata A
J Mol Biol 1986 Dec 5;192(3):549-56
PubMed ID: 3550103
Regulation of the phosphate regulon of Escherichia coli: analysis of mutant phoB and phoR genes causing different phenotypes.
Yamada M, Makino K, Amemura M, Shinagawa H, Nakata A
J Bacteriol 1989 Oct;171(10):5601-6
PubMed ID: 2676981
Regulation of the phosphate regulon of Escherichia coli: properties of phoR deletion mutants and subcellular localization of PhoR protein.
Yamada M, Makino K, Shinagawa H, Nakata A
Mol Gen Genet 1990 Feb;220(3):366-72
PubMed ID: 2187152