Pseudomonas aeruginosa UCBPP-PA14, PA14_20580 (amiC)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_20580
Name	amiC
Replicon	chromosome
Genomic location	1770873 - 1772030 (+ strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	1 transposon mutants in orthologs

Cross-References

RefSeq	YP_789788.1
GI	116051379
Entrez	4382277
INSDC	ABJ12615.1
NCBI Locus Tag	PA14_20580
UniParc	UPI0000165ECF
UniProtKB Acc	Q02QJ8
UniProtKB ID	Q02QJ8_PSEAB
UniRef100	UniRef100_P27017
UniRef50	UniRef50_P27017
UniRef90	UniRef90_P27017

Product

Feature Type	CDS
Coding Frame	1
Product Name	aliphatic amidase expression-regulating protein
Synonyms
Evidence for Translation
Charge (pH 7)	-6.74
Kyte-Doolittle Hydrophobicity Value	-0.313
Molecular Weight (kDa)	42.8
Isoelectric Point (pI)	5.82

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
1QO0	BINDING PROTEIN	10/26/99	Amide receptor of the amidase operon of Pseudomonas aeruginosa (AmiC) complexed with the negative regulator AmiR.	PSEUDOMONAS AERUGINOSA	2.25	X-RAY DIFFRACTION	98.7
1PEA	BINDING PROTEIN	11/16/95	AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH ACETAMIDE	Pseudomonas aeruginosa	2.1	X-RAY DIFFRACTION	98.7
1QNL	TRANSFERASE	10/19/99	AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH BUTYRAMIDE	PSEUDOMONAS AERUGINOSA	2.7	X-RAY DIFFRACTION	98.4

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name	Source Accession	Source DB	Version	Target Accession	Target Description	Percent Identity	Alignment Length	E-Value
Butyramide	DB02121	DrugBank	5.1.4	P27017	Aliphatic amidase expression-regulating protein	100.0	385	7.1e-227
Acetamide	DB02736	DrugBank	5.1.4	P27017	Aliphatic amidase expression-regulating protein	100.0	385	7.1e-227

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 242 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002264 (348 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_20580 Search term: amiC Search term: aliphatic amidase expression-regulating protein

Human Homologs

References