Pseudomonas aeruginosa UCBPP-PA14, PA14_28690 (pheS)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_28690
Name	pheS
Replicon	chromosome
Genomic location	2470426 - 2471442 (+ strand)

Cross-References

RefSeq	YP_790449.1
GI	116050730
EC Number	6.1.1.20
Entrez	4380754
INSDC	ABJ11966.1
NCBI Locus Tag	PA14_28690
UniParc	UPI0000395EAC
UniProtKB Acc	Q02NN7
UniProtKB ID	SYFA_PSEAB
UniRef100	UniRef100_Q02NN7
UniRef50	UniRef50_Q5F9U0
UniRef90	UniRef90_Q9I0A3

Product

Feature Type	CDS
Coding Frame	1
Product Name	phenylalanyl-tRNA synthetase subunit alpha
Synonyms
Evidence for Translation
Charge (pH 7)	-7.58
Kyte-Doolittle Hydrophobicity Value	-0.248
Molecular Weight (kDa)	38.0
Isoelectric Point (pI)	5.79

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
4P75	LIGASE/LIGASE INHIBITOR	03/25/14	PheRS in complex with compound 4a	Pseudomonas aeruginosa	2.96	X-RAY DIFFRACTION	99.7
4P71	LIGASE	03/25/14	Apo PheRS from P. aeuriginosa	Pseudomonas aeruginosa	2.79	X-RAY DIFFRACTION	99.7
4P73	LIGASE/LIGASE Inhibitor	03/25/14	PheRS in complex with compound 1a	Pseudomonas aeruginosa	3.03	X-RAY DIFFRACTION	99.7
4P72	LIGASE/LIGASE INHIBITOR	03/25/14	PheRS in complex with compound 2a	Pseudomonas aeruginosa	2.62	X-RAY DIFFRACTION	99.7
4P74	LIGASE/LIGASE INHIBITOR	03/25/14	PheRS in complex with compound 3a	Pseudomonas aeruginosa	2.7	X-RAY DIFFRACTION	99.7

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 666 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002831 (535 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_28690 Search term: pheS Search term: phenylalanyl-tRNA synthetase subunit alpha

Human Homologs

References