Pseudomonas aeruginosa UCBPP-PA14, PA14_32390 (mexF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_32390
Name
mexF
Replicon chromosome
Genomic location 2814154 - 2817342 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 23 transposon mutants in orthologs

Cross-References

RefSeq YP_790743.1
GI 116050438
Entrez 4382681
INSDC ABJ11674.1
NCBI Locus Tag PA14_32390
UniParc UPI00000C5704
UniProtKB Acc Q02MU3
UniProtKB ID Q02MU3_PSEAB
UniRef100 UniRef100_Q9I0Y8
UniRef50 UniRef50_Q8EBL9
UniRef90 UniRef90_Q9I0Y8

Product

Feature Type CDS
Coding Frame 1
Product Name
RND multidrug efflux transporter MexF
Synonyms
Evidence for Translation
Charge (pH 7) -11.43
Kyte-Doolittle Hydrophobicity Value 0.284
Molecular Weight (kDa) 115.5
Isoelectric Point (pI) 5.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexF MexF is the multidrug inner membrane transporter of the MexEF-OprN complex. mexF corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: mexF/mexB) and 4 loci in Pseudomonas aeruginosa LESB58 (gene name: mexD/mexB). [PMID:10515918] ARO:3000804 protein homolog model Perfect 2016.5 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 488 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000417 (2093 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_32390
Search term: mexF

Human Homologs

References

No references are associated with this feature.