Pseudomonas aeruginosa UCBPP-PA14, PA14_36910 (ligD)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_36910
Name	ligD
Replicon	chromosome
Genomic location	3287787 - 3290309 (- strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	2 transposon mutants in orthologs

Cross-References

RefSeq	YP_791107.1
GI	116050079
EC Number	6.5.1.1
Entrez	4385768
INSDC	ABJ11315.1
NCBI Locus Tag	PA14_36910
UniParc	UPI00003969CE
UniProtKB Acc	Q02LS9
UniProtKB ID	Q02LS9_PSEAB
UniRef100	UniRef100_S0IQ94
UniRef50	UniRef50_Q9I1X7
UniRef90	UniRef90_Q9I1X7

Product

Feature Type	CDS
Coding Frame	1
Product Name	ATP-dependent DNA ligase
Synonyms
Evidence for Translation
Charge (pH 7)	17.94
Kyte-Doolittle Hydrophobicity Value	-0.522
Molecular Weight (kDa)	94.0
Isoelectric Point (pI)	9.59

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
3N9B	LIGASE	05/28/10	Crystal Structure of the P. aeruginosa LigD phosphoesterase domain	Pseudomonas aeruginosa	1.92	X-RAY DIFFRACTION	98.8
3N9D	LIGASE	05/28/10	Monoclinic Structure of P. aeruginosa LigD phosphoesterase domain	Pseudomonas aeruginosa	2.3	X-RAY DIFFRACTION	98.8
2LJ6	DNA BINDING PROTEIN	09/06/11	Solution Structure and DNA-binding Properties of the Phosphoesterase Domain of DNA Ligase D	Pseudomonas aeruginosa	NOT	SOLUTION NMR	98.9
2FAQ	HYDROLASE/TRANSFERASE	12/07/05	Crystal Structure of Pseudomonas aeruginosa LigD polymerase domain with ATP and Manganese	Pseudomonas aeruginosa	1.9	X-RAY DIFFRACTION	99.7
2FAR	Hydrolase/Transferase	12/07/05	Crystal Structure of Pseudomonas aeruginosa LigD polymerase domain with dATP and Manganese	Pseudomonas aeruginosa	1.9	X-RAY DIFFRACTION	99.7
2FAO	HYDROLASE/TRANSFERASE	12/07/05	Crystal Structure of Pseudomonas aeruginosa LigD polymerase domain	Pseudomonas aeruginosa	1.5	X-RAY DIFFRACTION	99.7

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 291 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG003336 (490 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_36910 Search term: ligD Search term: ATP-dependent DNA ligase

Human Homologs

References