Strain |
Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest |
Locus Tag |
PA14_39020
|
Name |
eptA
|
Replicon | chromosome |
Genomic location | 3478895 - 3480598 (- strand) |
Transposon Mutants | 2 transposon mutants in UCBPP-PA14 |
Transposon Mutants in orthologs | 4 transposon mutants in orthologs |
Comment | Overexpression of three P. aeruginosa eptA homologs in E. coli (PA14_39020 , PA14_58610, PA14_21210) revealed that PA14_39020 was able to modify lipid A with phosphoehthanolamine (PMID:25846400) |
RefSeq | YP_791268.1 |
GI | 116049923 |
Entrez | 4382769 |
INSDC | ABJ11159.1 |
NCBI Locus Tag | PA14_39020 |
UniParc | UPI000045D239 |
UniProtKB Acc | Q02LB8 |
UniProtKB ID | Q02LB8_PSEAB |
UniRef100 | UniRef100_W0Z324 |
UniRef50 | UniRef50_S2FPC3 |
UniRef90 | UniRef90_Q9I2D3 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
lipid A phosphoethanolamine transferase, EptA
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -0.92 |
Kyte-Doolittle Hydrophobicity Value | 0.035 |
Molecular Weight (kDa) | 62.3 |
Isoelectric Point (pI) | 6.83 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 137 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003461 (883 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA14_39020
Search term: eptA
Search term: lipid A phosphoethanolamine transferase, EptA
|
Extracellular zinc induces phosphoethanolamine addition to Pseudomonas aeruginosa lipid A via the ColRS two-component system.
Nowicki EM, O'Brien JP, Brodbelt JS, Trent MS
Mol Microbiol 2015 Jul;97(1):166-78
PubMed ID: 25846400
|
Exogenous and Endogenous Phosphoethanolamine Transferases Differently Affect Colistin Resistance and Fitness in Pseudomonas aeruginosa.
Cervoni M, Lo Sciuto A, Bianchini C, Mancone C, Imperi F
Front Microbiol 2021;12:778968
PubMed ID: 34777328
|
Regulatory Landscape of the Pseudomonas aeruginosa Phosphoethanolamine Transferase Gene eptA in the Context of Colistin Resistance.
Cervoni M, Sposato D, Lo Sciuto A, Imperi F
Antibiotics (Basel) 2023 Jan 18;12(2)
PubMed ID: 36830112
|
New insights about the EptA protein and its correlation with the pmrC gene in polymyxin resistance in Pseudomonas aeruginosa.
Freire CMADS, Taunay-Rodrigues A, Gonzatti MB, Fonseca FMP, Freire JEDC
Curr Res Microb Sci 2021 Dec;2:100042
PubMed ID: 34841333
|