Pseudomonas aeruginosa UCBPP-PA14, PA14_39925 (phzD2)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_39925
Name	phzD2
Replicon	chromosome
Genomic location	3558859 - 3559482 (- strand)

Cross-References

RefSeq	YP_791337.1
GI	116054445
Entrez	4384044
INSDC	ABJ15681.1
NCBI Locus Tag	PA14_39925
UniParc	UPI0000E44AE0
UniProtKB Acc	Q02L49
UniProtKB ID	Q02L49_PSEAB
UniRef100	UniRef100_Q02L49
UniRef50	UniRef50_Q51790
UniRef90	UniRef90_Q7DC80

Product

Feature Type	CDS
Coding Frame	1
Product Name	phenazine biosynthesis protein PhzD
Synonyms
Evidence for Translation
Charge (pH 7)	-1.90
Kyte-Doolittle Hydrophobicity Value	-0.096
Molecular Weight (kDa)	23.2
Isoelectric Point (pI)	6.35

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
1NF9	HYDROLASE	12/13/02	Crystal Structure of PhzD protein from Pseudomonas aeruginosa	Pseudomonas aeruginosa	1.5	X-RAY DIFFRACTION	99.5
1NF8	HYDROLASE	12/13/02	Crystal structure of PhzD protein active site mutant with substrate	Pseudomonas aeruginosa	1.6	X-RAY DIFFRACTION	99.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name	Source Accession	Source DB	Version	Target Accession	Target Description	Percent Identity	Alignment Length	E-Value
Isochorismic Acid	DB02793	DrugBank	5.1.4	Q7DC80	Phenazine biosynthesis protein PhzD	99.5	207	1.0e-115
Formic acid	DB01942	DrugBank	5.1.4	Q7DC80	Phenazine biosynthesis protein PhzD	99.5	207	1.0e-115

Virulence Evidence

Source 1
Database	PseudoCAP
Category	Phenazine biosynthesis
Evidence	ECO:0000316 genetic interaction evidence used in manual assertion
Host Organism	Mus musculus
Notes	phz2 operon, but not phz1 operon required for lung colonization in acute mouse pulmonary Infection model
Infection model	acute mouse pulmonary Infection model
Reference	23129634

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 233 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG014911 (1 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_39925 Search term: phzD2 Search term: phenazine biosynthesis protein PhzD

Human Homologs

References