Pseudomonas aeruginosa UCBPP-PA14, PA14_40670 (metH)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_40670
Name	metH
Replicon	chromosome
Genomic location	3631084 - 3634788 (+ strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	2 transposon mutants in orthologs

Cross-References

RefSeq	YP_791398.1
GI	116049795
EC Number	2.1.1.13
Entrez	4380265
INSDC	ABJ11031.1
NCBI Locus Tag	PA14_40670
UniParc	UPI000045D1FB
UniProtKB Acc	Q02KY8
UniProtKB ID	Q02KY8_PSEAB
UniRef100	UniRef100_Q02KY8
UniRef50	UniRef50_P13009
UniRef90	UniRef90_Q9I2Q2

Product

Feature Type	CDS
Coding Frame	1
Product Name	B12-dependent methionine synthase
Synonyms
Evidence for Translation
Charge (pH 7)	-54.05
Kyte-Doolittle Hydrophobicity Value	-0.154
Molecular Weight (kDa)	135.0
Isoelectric Point (pI)	4.60

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 504 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG003557 (535 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_40670 Search term: metH Search term: B12-dependent methionine synthase

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000441845 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] E-value: 0.0e+00 Percent Identity: 52.2
Ensembl 110, assembly GRCh38.p14	ENSP00000355536 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] E-value: 0.0e+00 Percent Identity: 54.7
Ensembl 110, assembly GRCh38.p14	ENSP00000505600 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] E-value: 0.0e+00 Percent Identity: 52.3
Ensembl 110, assembly GRCh38.p14	ENSP00000502299 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] E-value: 0.0e+00 Percent Identity: 54.5
Ensembl 110, assembly GRCh38.p14	ENSP00000506109 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] E-value: 0.0e+00 Percent Identity: 51.2

References