Pseudomonas aeruginosa UCBPP-PA14, PA14_64980 (nadE)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_64980
Name	nadE
Replicon	chromosome
Genomic location	5791079 - 5791906 (+ strand)
Transposon Mutants in orthologs	1 transposon mutants in orthologs

Cross-References

RefSeq	YP_793388.1
GI	116053069
EC Number	6.3.1.5
Entrez	4380843
INSDC	ABJ14305.1
NCBI Locus Tag	PA14_64980
UniParc	UPI0000396F26
UniProtKB Acc	Q02F98
UniProtKB ID	NADE_PSEAB
UniRef100	UniRef100_Q02F98
UniRef50	UniRef50_Q8D3T7
UniRef90	UniRef90_A6VD32

Product

Feature Type	CDS
Coding Frame	1
Product Name	NAD synthetase
Synonyms
Evidence for Translation
Charge (pH 7)	-6.37
Kyte-Doolittle Hydrophobicity Value	-0.183
Molecular Weight (kDa)	29.7
Isoelectric Point (pI)	5.38

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
4XFD	LIGASE	12/26/14	Crystal Structure of a NH(3)-dependent NAD(+) synthetase from Pseudomonas aeruginosa	Pseudomonas aeruginosa	1.55	X-RAY DIFFRACTION	99.6
5F23	LIGASE	12/01/15	Crystal structure of NH(3)-dependent NAD(+) synthetase Pseudomonas aeruginosa in complex with NAD	Pseudomonas aeruginosa	1.5	X-RAY DIFFRACTION	99.6

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 583 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG004537 (530 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_64980 Search term: nadE Search term: NAD synthetase

Human Homologs

References