Pseudomonas aeruginosa M18, PAM18_1984 (murB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa M18
GCF_000226155.1|latest
Locus Tag
PAM18_1984
Name
murB
Replicon chromosome
Genomic location 2180920 - 2181939 (+ strand)

Cross-References

RefSeq YP_005974572.1
GI 386058050
Entrez 12566026
NCBI Locus Tag PAM18_1984

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-N-acetylenolpyruvoylglucosamine reductase
Synonyms
Evidence for Translation
Charge (pH 7) -0.87
Kyte-Doolittle Hydrophobicity Value -0.246
Molecular Weight (kDa) 37.7
Isoelectric Point (pI) 6.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7ORZ OXIDOREDUCTASE 06/06/21 Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) Pseudomonas aeruginosa PAO1 1.85 X-RAY DIFFRACTION 99.4
7OSQ OXIDOREDUCTASE 06/09/21 Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.07 X-RAY DIFFRACTION 99.4
4JAY OXIDOREDUCTASE 02/19/13 Crystal structure of P. aeruginosa MurB in complex with NADP+ Pseudomonas aeruginosa 2.23 X-RAY DIFFRACTION 99.4
4JB1 OXIDOREDUCTASE 02/19/13 Crystal structure of P. aeruginosa MurB in complex with NADP+ Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 99.4
7OR2 OXIDOREDUCTASE 06/04/21 Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 4) Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.35 X-RAY DIFFRACTION 99.4

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 550 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002605 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PAM18_1984
Search term: murB

Human Homologs

References

No references are associated with this feature.