Pseudomonas aeruginosa M18, PAM18_3701 (lasR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa M18
GCF_000226155.1|latest
Locus Tag
PAM18_3701
Name
lasR
Replicon chromosome
Genomic location 4107587 - 4108306 (- strand)

Cross-References

RefSeq YP_005976284.1
GI 386059762
Entrez 12567755
NCBI Locus Tag PAM18_3701

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator LasR
Synonyms
Evidence for Translation
Charge (pH 7) -1.68
Kyte-Doolittle Hydrophobicity Value -0.020
Molecular Weight (kDa) 26.6
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2UV0 TRANSCRIPTION 03/08/07 Structure of the P. aeruginosa LasR ligand-binding domain bound to its autoinducer PSEUDOMONAS AERUGINOSA 1.8 X-RAY DIFFRACTION 100.0
6MVN TRANSCRIPTION 10/26/18 LasR LBD L130F:3OC10HSL complex Pseudomonas aeruginosa (strain UCBPP-PA14) 2.2 X-RAY DIFFRACTION 99.6
6V7X DNA BINDING PROTEIN/Viral protein 12/09/19 Structure of a phage-encoded quorum sensing anti-activator, Aqs1 bound to LasR Pseudomonas aeruginosa (strain UCBPP-PA14); Pseudomonas virus DMS3 2.9 X-RAY DIFFRACTION 100.0
6V7W DNA BINDING PROTEIN/Viral protein 12/09/19 Crystal structure of LasR-Aqs1 complex from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain UCBPP-PA14); Pseudomonas virus DMS3 3 X-RAY DIFFRACTION 100.0
3IX3 TRANSCRIPTION 09/03/09 LasR-OC12 HSL complex Pseudomonas aeruginosa 1.4 X-RAY DIFFRACTION 100.0
6MWL TRANSCRIPTION 10/29/18 LasR LBD:mBTL complex Pseudomonas aeruginosa (strain UCBPP-PA14) 1.5 X-RAY DIFFRACTION 100.0
6MWH TRANSCRIPTION 10/29/18 LasR LBD:BB0020 complex Pseudomonas aeruginosa (strain UCBPP-PA14) 2.2 X-RAY DIFFRACTION 100.0
3IX4 TRANSCRIPTION 09/03/09 LasR-TP1 complex Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 100.0
6MWW TRANSCRIPTION 10/30/18 LasR LBD:BB0126 complex Pseudomonas aeruginosa (strain UCBPP-PA14) 2.76 X-RAY DIFFRACTION 100.0
3JPU TRANSCRIPTION 09/04/09 LasR-TP4 complex Pseudomonas aeruginosa 2.3 X-RAY DIFFRACTION 100.0
3IX8 TRANSCRIPTION 09/03/09 LasR-TP3 complex Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 100.0
6MWZ TRANSCRIPTION 10/30/18 LasR LBD T75V/Y93F/A127W:BB0126 Pseudomonas aeruginosa (strain UCBPP-PA14); Pseudomonas aeruginosa UCBPP-PA14 1.657 X-RAY DIFFRACTION 98.7

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE DB08324 DrugBank 5.1.4 P25084 Transcriptional activator protein LasR 100.0 239 2.3e-135

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 142 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001096 (1439 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PAM18_3701
Search term: lasR

Human Homologs

References

No references are associated with this feature.