Pseudomonas aeruginosa M18, PAM18_4052 (pqsA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa M18
GCF_000226155.1|latest
Locus Tag
PAM18_4052
Name
pqsA
Replicon chromosome
Genomic location 4487096 - 4488649 (- strand)

Cross-References

RefSeq YP_005976635.1
GI 386060113
Entrez 12568107
NCBI Locus Tag PAM18_4052

Product

Feature Type CDS
Coding Frame 1
Product Name
putative coenzyme A ligase
Synonyms
Evidence for Translation
Charge (pH 7) -6.98
Kyte-Doolittle Hydrophobicity Value -0.068
Molecular Weight (kDa) 56.6
Isoelectric Point (pI) 6.15

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5OE6 LIGASE 07/07/17 Crystal structure of the N-terminal domain of PqsA in complex with 6-fluoroanthraniloyl-AMP (crystal form 1) Pseudomonas aeruginosa PAO1 1.67 X-RAY DIFFRACTION 100.0
5OE5 LIGASE 07/07/17 Crystal structure of the N-terminal domain of PqsA in complex with anthraniloyl-AMP (crystal form 3) Pseudomonas aeruginosa PAO1 1.74 X-RAY DIFFRACTION 100.0
5OE3 LIGASE 07/07/17 Crystal structure of the N-terminal domain of PqsA in complex with anthraniloyl-AMP (crystal form 1) Pseudomonas aeruginosa PAO1 1.43 X-RAY DIFFRACTION 100.0
5OE4 LIGASE 07/07/17 Crystal structure of the N-terminal domain of PqsA in complex with anthraniloyl-AMP (crystal form 2) Pseudomonas aeruginosa PAO1 1.904 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 599 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000959 (296 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PAM18_4052
Search term: pqsA

Human Homologs

Ensembl 110, assembly GRCh38.p14
acyl-CoA synthetase short chain family member 1 [Source:HGNC Symbol;Acc:HGNC:16091]
E-value: 1.6e-24
Percent Identity: 24.3
Ensembl 110, assembly GRCh38.p14
acyl-CoA synthetase short chain family member 1 [Source:HGNC Symbol;Acc:HGNC:16091]
E-value: 1.6e-24
Percent Identity: 24.3

References

No references are associated with this feature.