Pseudomonas aeruginosa M18, PAM18_4111 (gacS)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa M18
GCF_000226155.1|latest |
| Locus Tag |
PAM18_4111
|
| Name |
gacS
|
| Replicon | chromosome |
| Genomic location | 4542388 - 4545165 (+ strand) |
Cross-References
| RefSeq | YP_005976694.1 |
| GI | 386060172 |
| Entrez | 12568167 |
| NCBI Locus Tag | PAM18_4111 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
sensor/response regulator hybrid
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -34.52 |
| Kyte-Doolittle Hydrophobicity Value | -0.162 |
| Molecular Weight (kDa) | 101.1 |
| Isoelectric Point (pI) | 4.73 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 5O7J | SIGNALING PROTEIN | 06/09/17 | Structural insights into the periplasmic sensor domain of the GacS histidine kinase controlling biofilm formation in Pseudomonas aeruginosa | Pseudomonas aeruginosa | NOT | SOLUTION NMR | 100.0 |
| 7QZ2 | SIGNALING PROTEIN | 01/30/22 | Crystal structure of GacS D1 domain in complex with BeF3- | Pseudomonas aeruginosa | 1.87 | X-RAY DIFFRACTION | 100.0 |
| 7QZO | SIGNALING PROTEIN | 01/31/22 | Crystal structure of GacS D1 domain | Pseudomonas aeruginosa | 1.45 | X-RAY DIFFRACTION | 100.0 |
| 7Z8N | SIGNALING PROTEIN | 03/17/22 | GacS histidine kinase from Pseudomonas aeruginosa | Pseudomonas aeruginosa PAO1 | 2.64 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 624 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000894 (527 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PAM18_4111
Search term: gacS
Search term: sensor/response regulator hybrid
|
Human Homologs
References
No references are associated with this feature.