Pseudomonas aeruginosa M18, PAM18_4241 (prpB)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa M18
GCF_000226155.1|latest |
| Locus Tag |
PAM18_4241
|
| Name |
prpB
|
| Replicon | chromosome |
| Genomic location | 4680574 - 4681470 (+ strand) |
Cross-References
| RefSeq | YP_005976824.1 |
| GI | 386060302 |
| Entrez | 12568302 |
| NCBI Locus Tag | PAM18_4241 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
2-methylisocitrate lyase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -5.92 |
| Kyte-Doolittle Hydrophobicity Value | 0.032 |
| Molecular Weight (kDa) | 32.1 |
| Isoelectric Point (pI) | 5.20 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 6T5M | LYASE | 10/16/19 | Crystal structure of 2-methylisocitrate lyase (PrpB) from Pseudomonas aeruginosa in complex with Mg(II)-pyruvate. | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 1.76 | X-RAY DIFFRACTION | 100.0 |
| 6T4V | LYASE | 10/15/19 | Crystal structure of 2-methylisocitrate lyase (PrpB) from Pseudomonas aeruginosa in apo form. | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 1.807 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 342 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000769 (537 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PAM18_4241
Search term: prpB
Search term: 2-methylisocitrate lyase
|
Human Homologs
References
No references are associated with this feature.