Pseudomonas aeruginosa M18, PAM18_4296

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa M18
GCF_000226155.1|latest
Locus Tag
PAM18_4296
Name
Replicon chromosome
Genomic location 4744510 - 4745406 (+ strand)

Cross-References

RefSeq YP_005976879.1
GI 386060357
Entrez 12568357
NCBI Locus Tag PAM18_4296

Product

Feature Type CDS
Coding Frame 1
Product Name
putative 3-hydroxyisobutyrate dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7) -4.86
Kyte-Doolittle Hydrophobicity Value 0.244
Molecular Weight (kDa) 30.8
Isoelectric Point (pI) 5.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3Q3C OXIDOREDUCTASE 12/21/10 Crystal structure of a serine dehydrogenase from Pseudomonas aeruginosa pao1 in complex with NAD Pseudomonas aeruginosa 2.299 X-RAY DIFFRACTION 99.0
3OBB OXIDOREDUCTASE 08/06/10 Crystal structure of a possible 3-hydroxyisobutyrate Dehydrogenase from pseudomonas aeruginosa pao1 Pseudomonas aeruginosa 2.2 X-RAY DIFFRACTION 99.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 485 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000717 (830 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PAM18_4296

Human Homologs

Ensembl 110, assembly GRCh38.p14
3-hydroxyisobutyrate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4907]
E-value: 5.8e-64
Percent Identity: 45.3

References

No references are associated with this feature.