Pseudomonas aeruginosa M18, PAM18_4419 (pykA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa M18
GCF_000226155.1|latest |
| Locus Tag |
PAM18_4419
|
| Name |
pykA
|
| Replicon | chromosome |
| Genomic location | 4895961 - 4897412 (+ strand) |
Cross-References
| RefSeq | YP_005977002.1 |
| GI | 386060480 |
| Entrez | 12568486 |
| NCBI Locus Tag | PAM18_4419 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
pyruvate kinase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -2.24 |
| Kyte-Doolittle Hydrophobicity Value | -0.092 |
| Molecular Weight (kDa) | 52.3 |
| Isoelectric Point (pI) | 6.66 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 6QXL | TRANSFERASE | 03/07/19 | Crystal Structure of Pyruvate Kinase II (PykA) from Pseudomonas aeruginosa in complex with sodium malonate, magnesium and glucose-6-phosphate | Pseudomonas aeruginosa | 2.43 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 614 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG003926 (537 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PAM18_4419
Search term: pykA
Search term: pyruvate kinase
|
Human Homologs
|
Ensembl
110, assembly
GRCh38.p14
|
pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021]
E-value:
3.1e-67
Percent Identity:
36.7
|
|
Ensembl
110, assembly
GRCh38.p14
|
pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021]
E-value:
3.1e-67
Percent Identity:
36.7
|
|
Ensembl
110, assembly
GRCh38.p14
|
pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021]
E-value:
3.1e-67
Percent Identity:
36.7
|
|
Ensembl
110, assembly
GRCh38.p14
|
pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021]
E-value:
3.1e-67
Percent Identity:
36.7
|
References
No references are associated with this feature.