Strain |
Pseudomonas aeruginosa DK2
GCF_000271365.1|latest |
Locus Tag |
PADK2_01225
|
Name |
|
Replicon | chromosome |
Genomic location | 272266 - 273450 (- strand) |
RefSeq | YP_006480242.1 |
GI | 392981655 |
EC Number | 1.14.13.2 |
Entrez | 13171622 |
NCBI Locus Tag | PADK2_01225 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
4-hydroxybenzoate 3-monooxygenase
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -0.97 |
Kyte-Doolittle Hydrophobicity Value | -0.245 |
Molecular Weight (kDa) | 44.4 |
Isoelectric Point (pI) | 6.80 |
Individual Mappings | |
Additional evidence for subcellular localization |
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
1IUW | OXIDOREDUCTASE | 11/22/95 | P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-4-HYDROXYBENZOATE AT PH 7.4 | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 99.2 |
2PHH | OXIDOREDUCTASE | 06/19/89 | THE COENZYME ANALOGUE ADENOSINE 5-DIPHOSPHORIBOSE DISPLACES FAD IN THE ACTIVE SITE OF P-HYDROXYBENZOATE HYDROXYLASE. AN X-RAY CRYSTALLOGRAPHIC INVESTIGATION | Pseudomonas fluorescens | 2.7 | X-RAY DIFFRACTION | 99.7 |
1PXB | OXIDOREDUCTASE | 09/27/94 | CRYSTAL STRUCTURES OF MUTANT PSEUDOMONAS AERUGINOSA P-HYDROXYBENZOATE HYDROXYLASE: THE TYR201PHE, TYR385PHE, AND ASN300ASP VARIANTS | Pseudomonas aeruginosa | 2.3 | X-RAY DIFFRACTION | 99.0 |
1PHH | OXIDOREDUCTASE | 11/04/87 | CRYSTAL STRUCTURE OF P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH ITS REACTION PRODUCT 3,4-DIHYDROXYBENZOATE | Pseudomonas fluorescens | 2.3 | X-RAY DIFFRACTION | 99.7 |
1PBC | OXIDOREDUCTASE | 07/06/94 | CRYSTAL STRUCTURES OF WILD-TYPE P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE, 2,4-DIHYDROXYBENZOATE AND 2-HYDROXY-4-AMINOBENZOATE AND OF THE TRY222ALA MUTANT, COMPLEXED WITH 2-HYDROXY-4-AMINOBENZOATE. EVIDENCE FOR A PROTON CHANNEL AND A NEW BINDING MODE OF THE FLAVIN RING | Pseudomonas fluorescens | 2.8 | X-RAY DIFFRACTION | 99.5 |
1DOC | OXIDOREDUCTASE | 09/06/94 | THE MOBIL FLAVIN OF 4-OH BENZOATE HYDROXYLASE: MOTION OF A PROSTHETIC GROUP REGULATES CATALYSIS | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 99.2 |
1IUU | OXIDOREDUCTASE | 11/22/95 | P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE AT PH 9.4 | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 99.2 |
1K0L | HYDROLASE | 09/19/01 | Pseudomonas aeruginosa phbh R220Q free of p-OHB | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 99.0 |
1D7L | OXIDOREDUCTASE | 10/18/99 | STRUCTURE-FUNCTION CORRELATIONS OF THE REACTION OF REDUCED NICOTINAMIDE ANALOGS WITH P-HYDROXYBENZOATE HYDROXYLASE SUBSTITUTED WITH A SERIES OF 8-SUBSTITUTED FLAVINS | Pseudomonas aeruginosa | 2.2 | X-RAY DIFFRACTION | 99.2 |
1K0I | HYDROLASE | 09/19/01 | Pseudomonas aeruginosa phbh R220Q in complex with 100mM PHB | Pseudomonas aeruginosa | 1.8 | X-RAY DIFFRACTION | 99.0 |
6JU1 | OXIDOREDUCTASE | 04/12/19 | p-Hydroxybenzoate hydroxylase Y385F mutant complexed with 3,4-dihydroxybenzoate | Pseudomonas aeruginosa | 1.6 | X-RAY DIFFRACTION | 99.0 |
1PBB | OXIDOREDUCTASE | 07/06/94 | CRYSTAL STRUCTURES OF WILD-TYPE P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE, 2,4-DIHYDROXYBENZOATE AND 2-HYDROXY-4-AMINOBENZOATE AND OF THE TRY222ALA MUTANT, COMPLEXED WITH 2-HYDROXY-4-AMINOBENZOATE. EVIDENCE FOR A PROTON CHANNEL AND A NEW BINDING MODE OF THE FLAVIN RING | Pseudomonas fluorescens | 2.5 | X-RAY DIFFRACTION | 99.5 |
1IUS | OXIDOREDUCTASE | 11/22/95 | P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE AT PH 5.0 | Pseudomonas aeruginosa | 2.2 | X-RAY DIFFRACTION | 99.2 |
1K0J | HYDROLASE | 09/19/01 | Pseudomonas aeruginosa phbh R220Q in complex with NADPH and free of p-OHB | Pseudomonas aeruginosa | 2.2 | X-RAY DIFFRACTION | 99.0 |
1DOE | OXIDOREDUCTASE | 09/06/94 | THE MOBIL FLAVIN OF 4-OH BENZOATE HYDROXYLASE: MOTION OF A PROSTHETIC GROUP REGULATES CATALYSIS | Pseudomonas aeruginosa | 2.3 | X-RAY DIFFRACTION | 99.2 |
1IUT | OXIDOREDUCTASE | 11/22/95 | P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE AT PH 7.4 | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 99.2 |
1PBE | OXIDOREDUCTASE | 07/06/94 | CRYSTAL STRUCTURE OF THE P-HYDROXYBENZOATE HYDROXYLASE-SUBSTRATE COMPLEX REFINED AT 1.9 ANGSTROMS RESOLUTION. ANALYSIS OF THE ENZYME-SUBSTRATE AND ENZYME-PRODUCT COMPLEXES | Pseudomonas fluorescens | 1.9 | X-RAY DIFFRACTION | 99.7 |
1PDH | OXIDOREDUCTASE | 12/01/94 | CRYSTAL STRUCTURE OF P-HYDROXYBENZOATE HYDROXYLASE RECONSTITUTED WITH THE MODIFIED FAD PRESENT IN ALCOHOL OXIDASE FROM METHYLOTROPHIC YEASTS: EVIDENCE FOR AN ARABINOFLAVIN | Pseudomonas fluorescens | 2.1 | X-RAY DIFFRACTION | 99.7 |
1PBD | OXIDOREDUCTASE | 07/06/94 | CRYSTAL STRUCTURES OF WILD-TYPE P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE, 2,4-DIHYDROXYBENZOATE AND 2-HYDROXY-4-AMINOBENZOATE AND OF THE TRY222ALA MUTANT, COMPLEXED WITH 2-HYDROXY-4-AMINOBENZOATE. EVIDENCE FOR A PROTON CHANNEL AND A NEW BINDING MODE OF THE FLAVIN RING | Pseudomonas fluorescens | 2.3 | X-RAY DIFFRACTION | 99.5 |
1YKJ | OXIDOREDUCTASE | 01/18/05 | A45G p-hydroxybenzoate hydroxylase with p-hydroxybenzoate bound | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 99.0 |
1DOD | OXIDOREDUCTASE | 09/06/94 | THE MOBIL FLAVIN OF 4-OH BENZOATE HYDROXYLASE: MOTION OF A PROSTHETIC GROUP REGULATES CATALYSIS | Pseudomonas aeruginosa | 2.1 | X-RAY DIFFRACTION | 99.2 |
1DOB | OXIDOREDUCTASE | 09/06/94 | THE MOBIL FLAVIN OF 4-OH BENZOATE HYDROXYLASE: MOTION OF A PROSTHETIC GROUP REGULATES CATALYSIS | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 99.0 |
1IUV | OXIDOREDUCTASE | 11/22/95 | P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-4-HYDROXYBENZOATE AT PH 5.0 | Pseudomonas aeruginosa | 2.5 | X-RAY DIFFRACTION | 99.2 |
1IUX | OXIDOREDUCTASE | 11/22/95 | P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-4-HYDROXYBENZOATE AT PH 9.4 | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 99.2 |
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
Aminobenzoic acid | DB02362 | DrugBank | 5.1.4 | P00438 | p-hydroxybenzoate hydroxylase | 99.7 | 394 | 2.3e-228 |
Adenosine-5-Diphosphoribose | DB02059 | DrugBank | 5.1.4 | P00438 | p-hydroxybenzoate hydroxylase | 99.7 | 394 | 2.3e-228 |
P-Hydroxybenzoic Acid | DB04242 | DrugBank | 5.1.4 | P00438 | p-hydroxybenzoate hydroxylase | 99.7 | 394 | 2.3e-228 |
Flavin adenine dinucleotide | DB03147 | DrugBank | 5.1.4 | P00438 | p-hydroxybenzoate hydroxylase | 99.7 | 394 | 2.3e-228 |
2,4-Dihydroxybenzoic Acid | DB02839 | DrugBank | 5.1.4 | P00438 | p-hydroxybenzoate hydroxylase | 99.7 | 394 | 2.3e-228 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 153 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000245 (499 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PADK2_01225
Search term: 4-hydroxybenzoate 3-monooxygenase
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