Pseudomonas aeruginosa DK2, PADK2_02135
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa DK2
GCF_000271365.1|latest |
| Locus Tag |
PADK2_02135
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 465312 - 465743 (- strand) |
Cross-References
| RefSeq | YP_006480424.1 |
| GI | 392981837 |
| Entrez | 13171965 |
| NCBI Locus Tag | PADK2_02135 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
multidrug resistance operon repressor MexR
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -3.65 |
| Kyte-Doolittle Hydrophobicity Value | -0.350 |
| Molecular Weight (kDa) | 16.5 |
| Isoelectric Point (pI) | 5.92 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AMR gene predictions from CARD database
Identified using the Resistance Gene Identifier (RGI)
| Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
| MexR | MexR is the repressor of the MexRAB-OprM operon. Mutant forms of mexR result in up-regulation of efflux pump system MexAB-OprM. [PMID:14526032, PMID:12727072, PMID:20616806, PMID:18812515] | ARO:3000506 | protein overexpression model | Strict | 284.3 | 99.3 | 3.2.5 |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 3ECH | Transcription, Transcription regulation | 08/30/08 | The MarR-family repressor MexR in complex with its antirepressor ArmR | Pseudomonas aeruginosa | 1.802 | X-RAY DIFFRACTION | 97.8 |
| 1LNW | TRANSCRIPTION REPRESSOR | 05/03/02 | CRYSTAL STRUCTURE OF THE MEXR REPRESSOR OF THE MEXAB-OPRM MULTIDRUG EFFLUX OPERON OF PSEUDOMONAS AERUGINOSA | Pseudomonas aeruginosa | 2.1 | X-RAY DIFFRACTION | 99.3 |
| 3MEX | Transcription, Transcription Regulation | 04/01/10 | Crystal structure of MexR in oxidized state | Pseudomonas aeruginosa | 2.1 | X-RAY DIFFRACTION | 98.6 |
| 4ZZL | TRANSCRIPTION | 04/10/15 | MexR R21W derepressor mutant causing multidrug resistance in P. aeruginosa by mexAB-oprM efflux pump expression | PSEUDOMONAS AERUGINOSA | 2.19 | X-RAY DIFFRACTION | 98.5 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 210 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000415 (299 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PADK2_02135
Search term: multidrug resistance operon repressor MexR
|
Human Homologs
References
No references are associated with this feature.