Pseudomonas aeruginosa DK2, PADK2_12770
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa DK2
GCF_000271365.1|latest |
| Locus Tag |
PADK2_12770
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 2703585 - 2705003 (- strand) |
Cross-References
| RefSeq | YP_006482537.1 |
| GI | 392983950 |
| Entrez | 13175391 |
| NCBI Locus Tag | PADK2_12770 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
Multidrug efflux outer membrane protein OprN precursor
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -6.52 |
| Kyte-Doolittle Hydrophobicity Value | -0.291 |
| Molecular Weight (kDa) | 51.2 |
| Isoelectric Point (pI) | 5.08 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AMR gene predictions from CARD database
Identified using the Resistance Gene Identifier (RGI)
| Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
| OprN | OprN is the outer membrane channel component of the MexEF-OprN multidrug efflux complex. [PMID:10515918] | ARO:3000805 | protein homolog model | Perfect | 877.5 | 100.0 | 3.2.5 |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 5NSW | MEMBRANE PROTEIN | 04/27/17 | Xenon for tunnelling analysis of the efflux pump component OprN. | Pseudomonas aeruginosa PAO1 | 2.5 | X-RAY DIFFRACTION | 100.0 |
| 5AZP | MEMBRANE PROTEIN | 10/21/15 | Crystal structure of a membrane protein from Pseudomonas aeruginosa | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) | 1.69 | X-RAY DIFFRACTION | 100.0 |
| 5IUY | TRANSPORT PROTEIN | 03/18/16 | Structural insights of the outer-membrane channel OprN | Pseudomonas aeruginosa PAO1 | 2.29 | X-RAY DIFFRACTION | 100.0 |
| 5AZO | MEMBRANE PROTEIN | 10/21/15 | Crystal structure of a membrane protein from Pseudomonas aeruginosa | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) | 2.7 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 300 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG003062 (529 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PADK2_12770
|
Human Homologs
References
No references are associated with this feature.