Pseudomonas aeruginosa DK2, PADK2_28245 (dadX)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa DK2
GCF_000271365.1|latest |
| Locus Tag |
PADK2_28245
|
| Name |
dadX
|
| Replicon | chromosome |
| Genomic location | 6107663 - 6108736 (- strand) |
Cross-References
| RefSeq | YP_006485612.1 |
| GI | 392987025 |
| EC Number | 5.1.1.1 |
| Entrez | 13175948 |
| NCBI Locus Tag | PADK2_28245 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
alanine racemase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | 0.23 |
| Kyte-Doolittle Hydrophobicity Value | -0.005 |
| Molecular Weight (kDa) | 39.0 |
| Isoelectric Point (pI) | 7.05 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 1RCQ | ISOMERASE | 11/04/03 | The 1.45 A crystal structure of alanine racemase from a pathogenic bacterium, Pseudomonas aeruginosa, contains both internal and external aldimine forms | Pseudomonas aeruginosa | 1.45 | X-RAY DIFFRACTION | 99.4 |
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| D-Lysine | DB03252 | DrugBank | 5.1.4 | Q9HTQ2 | Alanine racemase, catabolic | 99.7 | 357 | 5.4e-205 |
| Lysine Nz-Carboxylic Acid | DB03801 | DrugBank | 5.1.4 | Q9HTQ2 | Alanine racemase, catabolic | 99.7 | 357 | 5.4e-205 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 560 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG004545 (850 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PADK2_28245
Search term: dadX
Search term: alanine racemase
|
Human Homologs
References
No references are associated with this feature.