Pseudomonas aeruginosa B136-33, G655_09905 (murB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa B136-33
GCF_000359505.1|latest
Locus Tag
G655_09905
Name
murB
Replicon chromosome
Genomic location 2143884 - 2144903 (+ strand)

Cross-References

RefSeq YP_007708828.1
GI 478478177
EC Number 1.1.1.158
Entrez 15134893
NCBI Locus Tag G655_09905

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-N-acetylenolpyruvoylglucosamine reductase
Synonyms
Evidence for Translation
Charge (pH 7) -0.87
Kyte-Doolittle Hydrophobicity Value -0.257
Molecular Weight (kDa) 37.6
Isoelectric Point (pI) 6.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4JB1 OXIDOREDUCTASE 02/19/13 Crystal structure of P. aeruginosa MurB in complex with NADP+ Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 99.7
7OR2 OXIDOREDUCTASE 06/04/21 Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 4) Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.35 X-RAY DIFFRACTION 99.7
4JAY OXIDOREDUCTASE 02/19/13 Crystal structure of P. aeruginosa MurB in complex with NADP+ Pseudomonas aeruginosa 2.23 X-RAY DIFFRACTION 99.7
7OSQ OXIDOREDUCTASE 06/09/21 Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.07 X-RAY DIFFRACTION 99.7
7ORZ OXIDOREDUCTASE 06/06/21 Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) Pseudomonas aeruginosa PAO1 1.85 X-RAY DIFFRACTION 99.7

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 548 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002605 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: G655_09905
Search term: murB

Human Homologs

References

No references are associated with this feature.