Pseudomonas aeruginosa B136-33, G655_28055 (pyrE)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa B136-33
GCF_000359505.1|latest |
| Locus Tag |
G655_28055
|
| Name |
pyrE
|
| Replicon | chromosome |
| Genomic location | 6157763 - 6158404 (- strand) |
Cross-References
| RefSeq | YP_007712441.1 |
| GI | 478481790 |
| EC Number | 2.4.2.10 |
| Entrez | 15138506 |
| NCBI Locus Tag | G655_28055 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
orotate phosphoribosyltransferase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -4.31 |
| Kyte-Doolittle Hydrophobicity Value | 0.031 |
| Molecular Weight (kDa) | 23336.4 |
| Isoelectric Point (pI) | 5.12 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| 5-O-phosphono-alpha-D-ribofuranosyl diphosphate | DB01632 | DrugBank | 5.1.4 | P08870 | Orotate phosphoribosyltransferase | 69.5 | 213 | 1.6e-82 |
| Orotic Acid | DB02262 | DrugBank | 5.1.4 | P08870 | Orotate phosphoribosyltransferase | 69.5 | 213 | 1.6e-82 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 360 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG004900 (536 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: G655_28055
Search term: pyrE
Search term: orotate phosphoribosyltransferase
|
Human Homologs
References
No references are associated with this feature.