Pseudomonas aeruginosa B136-33, G655_28070 (rph)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa B136-33
GCF_000359505.1|latest |
| Locus Tag |
G655_28070
|
| Name |
rph
|
| Replicon | chromosome |
| Genomic location | 6159741 - 6160460 (- strand) |
Cross-References
| RefSeq | YP_007712444.1 |
| GI | 478481793 |
| EC Number | 2.7.7.56 |
| Entrez | 15138509 |
| NCBI Locus Tag | G655_28070 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
ribonuclease PH
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -1.58 |
| Kyte-Doolittle Hydrophobicity Value | -0.183 |
| Molecular Weight (kDa) | 25.7 |
| Isoelectric Point (pI) | 5.89 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 1R6L | TRANSFERASE | 10/15/03 | Crystal Structure Of The tRNA Processing Enzyme Rnase pH From Pseudomonas Aeruginosa | Pseudomonas aeruginosa | 1.9 | X-RAY DIFFRACTION | 100.0 |
| 1R6M | TRANSFERASE | 10/15/03 | Crystal Structure Of The tRNA Processing Enzyme Rnase pH From Pseudomonas Aeruginosa In Complex With Phosphate | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 100.0 |
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| N-cyclohexyltaurine | DB03309 | DrugBank | 5.1.4 | P50597 | Ribonuclease PH | 100.0 | 239 | 1.8e-127 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 506 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG004903 (536 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: G655_28070
Search term: rph
Search term: ribonuclease PH
|
Human Homologs
References
No references are associated with this feature.