Pseudomonas entomophila L48, PSEEN4122 (crbR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas entomophila L48
GCF_000026105.1|latest
Locus Tag
PSEEN4122
Name
crbR
Replicon chromosome
Genomic location 4415886 - 4416536 (- strand)

Cross-References

RefSeq YP_609596.1
GI 104783098
Entrez 4089940
INSDC CAK16812.1
UniParc UPI0000D78D36
UniProtKB Acc Q1I6C3
UniProtKB ID Q1I6C3_PSEE4
UniRef100 UniRef100_Q1I6C3
UniRef50 UniRef50_Q4KHB4
UniRef90 UniRef90_Q4KHB4

Product

Feature Type CDS
Coding Frame 1
Product Name
response regulator CrbR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -6.55
Kyte-Doolittle Hydrophobicity Value 0.171
Molecular Weight (kDa) 23422.7
Isoelectric Point (pI) 4.67

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 546 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002070 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PSEEN4122
Search term: crbR

Human Homologs

References

Regulation of acetyl-CoA synthetase transcription by the CrbS/R two-component system is conserved in genetically diverse environmental pathogens.
Jacob K, Rasmussen A, Tyler P, Servos MM, Sylla M, Prado C, Daniele E, Sharp JS, Purdy AE
PLoS One 2017;12(5):e0177825
PubMed ID: 28542616