Pseudomonas aeruginosa 2192, PA2G_00406

Gene Feature Overview

Strain	Pseudomonas aeruginosa 2192 GCF_000152545.1|latest
Locus Tag	PA2G_00406
Name
Replicon	chromosome
Genomic location	439120 - 439839 (+ strand)

Cross-References

RefSeq	ZP_04933102.1
GI	254239780
NCBI Locus Tag	PA2G_00406
UniProtKB Acc	A3LBI3
UniProtKB ID	A3LBI3_PSEAE

Product

Feature Type	CDS
Coding Frame	1
Product Name	LuxR family transcriptional regulator
Synonyms
Evidence for Translation
Charge (pH 7)	-1.68
Kyte-Doolittle Hydrophobicity Value	-0.020
Molecular Weight (kDa)	26.6
Isoelectric Point (pI)	6.51

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
6MWH	TRANSCRIPTION	10/29/18	LasR LBD:BB0020 complex	Pseudomonas aeruginosa (strain UCBPP-PA14)	2.2	X-RAY DIFFRACTION	100.0
3JPU	TRANSCRIPTION	09/04/09	LasR-TP4 complex	Pseudomonas aeruginosa	2.3	X-RAY DIFFRACTION	100.0
6MVN	TRANSCRIPTION	10/26/18	LasR LBD L130F:3OC10HSL complex	Pseudomonas aeruginosa (strain UCBPP-PA14)	2.2	X-RAY DIFFRACTION	99.6
6MWW	TRANSCRIPTION	10/30/18	LasR LBD:BB0126 complex	Pseudomonas aeruginosa (strain UCBPP-PA14)	2.76	X-RAY DIFFRACTION	100.0
6V7W	DNA BINDING PROTEIN/Viral protein	12/09/19	Crystal structure of LasR-Aqs1 complex from Pseudomonas aeruginosa	Pseudomonas aeruginosa (strain UCBPP-PA14); Pseudomonas virus DMS3	3	X-RAY DIFFRACTION	100.0
6MWZ	TRANSCRIPTION	10/30/18	LasR LBD T75V/Y93F/A127W:BB0126	Pseudomonas aeruginosa (strain UCBPP-PA14); Pseudomonas aeruginosa UCBPP-PA14	1.657	X-RAY DIFFRACTION	98.7
3IX4	TRANSCRIPTION	09/03/09	LasR-TP1 complex	Pseudomonas aeruginosa	1.8	X-RAY DIFFRACTION	100.0
3IX3	TRANSCRIPTION	09/03/09	LasR-OC12 HSL complex	Pseudomonas aeruginosa	1.4	X-RAY DIFFRACTION	100.0
6V7X	DNA BINDING PROTEIN/Viral protein	12/09/19	Structure of a phage-encoded quorum sensing anti-activator, Aqs1 bound to LasR	Pseudomonas aeruginosa (strain UCBPP-PA14); Pseudomonas virus DMS3	2.9	X-RAY DIFFRACTION	100.0
3IX8	TRANSCRIPTION	09/03/09	LasR-TP3 complex	Pseudomonas aeruginosa	1.8	X-RAY DIFFRACTION	100.0
2UV0	TRANSCRIPTION	03/08/07	Structure of the P. aeruginosa LasR ligand-binding domain bound to its autoinducer	PSEUDOMONAS AERUGINOSA	1.8	X-RAY DIFFRACTION	100.0
6MWL	TRANSCRIPTION	10/29/18	LasR LBD:mBTL complex	Pseudomonas aeruginosa (strain UCBPP-PA14)	1.5	X-RAY DIFFRACTION	100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name	Source Accession	Source DB	Version	Target Accession	Target Description	Percent Identity	Alignment Length	E-Value
N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE	DB08324	DrugBank	5.1.4	P25084	Transcriptional activator protein LasR	100.0	239	2.3e-135

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001096 (1439 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2G_00406 Search term: LuxR family transcriptional regulator

Human Homologs

References