Pseudomonas fulva 12-X, Psefu_0189

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas fulva 12-X
GCF_000213805.1|latest
Locus Tag
Psefu_0189
Name
Replicon chromosome
Genomic location 208993 - 209634 (+ strand)

Cross-References

RefSeq YP_004472269.1
GI 333898396
EC Number 2.4.2.10
Entrez 10655369
INSDC AEF20175.1
NCBI Locus Tag Psefu_0189
UniParc UPI00020CC9D8
UniProtKB Acc F6AEA0
UniProtKB ID F6AEA0_PSEF1
UniRef100 UniRef100_F6AEA0
UniRef50 UniRef50_O94331
UniRef90 UniRef90_F6AEA0

Product

Feature Type CDS
Coding Frame 1
Product Name
orotate phosphoribosyltransferase
Synonyms
Evidence for Translation
Charge (pH 7) -5.07
Kyte-Doolittle Hydrophobicity Value 0.126
Molecular Weight (kDa) 23.1
Isoelectric Point (pI) 5.06

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
5-O-phosphono-alpha-D-ribofuranosyl diphosphate DB01632 DrugBank 5.1.4 P08870 Orotate phosphoribosyltransferase 70.0 213 1.6e-82
Orotic Acid DB02262 DrugBank 5.1.4 P08870 Orotate phosphoribosyltransferase 70.0 213 1.6e-82

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 350 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004900 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Psefu_0189

Human Homologs

References

No references are associated with this feature.