Pseudomonas aeruginosa 2192, PA2G_00567

Gene Feature Overview

Strain	Pseudomonas aeruginosa 2192 GCF_000152545.1|latest
Locus Tag	PA2G_00567
Name
Replicon	chromosome
Genomic location	609520 - 610956 (+ strand)

Cross-References

RefSeq	ZP_04933257.1
GI	254239935
NCBI Locus Tag	PA2G_00567
UniProtKB Acc	A3L7E8
UniProtKB ID	A3L7E8_PSEAE

Product

Feature Type	CDS
Coding Frame	1
Product Name	dihydrolipoamide dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7)	-0.22
Kyte-Doolittle Hydrophobicity Value	0.134
Molecular Weight (kDa)	50.2
Isoelectric Point (pI)	6.96

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
5U8U	OXIDOREDUCTASE	12/15/16	Dihydrolipoamide dehydrogenase (LpdG) from Pseudomonas aeruginosa	Pseudomonas aeruginosa (strain UCBPP-PA14)	1.35	X-RAY DIFFRACTION	99.8
5U8W	OXIDOREDUCTASE	12/15/16	Dihydrolipoamide dehydrogenase (LpdG) from Pseudomonas aeruginosa bound to NADH	Pseudomonas aeruginosa (strain UCBPP-PA14)	1.79	X-RAY DIFFRACTION	99.8
1LPF	OXIDOREDUCTASE	10/26/92	THREE-DIMENSIONAL STRUCTURE OF LIPOAMIDE DEHYDROGENASE FROM PSEUDOMONAS FLUORESCENS AT 2.8 ANGSTROMS RESOLUTION. ANALYSIS OF REDOX AND THERMOSTABILITY PROPERTIES	Pseudomonas fluorescens	2.8	X-RAY DIFFRACTION	99.6
5U8V	OXIDOREDUCTASE	12/15/16	Dihydrolipoamide dehydrogenase (LpdG) from Pseudomonas aeruginosa bound to NAD+	Pseudomonas aeruginosa (strain UCBPP-PA14)	1.45	X-RAY DIFFRACTION	99.8

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name	Source Accession	Source DB	Version	Target Accession	Target Description	Percent Identity	Alignment Length	E-Value
Flavin adenine dinucleotide	DB03147	DrugBank	5.1.4	P14218	Dihydrolipoyl dehydrogenase	99.6	478	3.7e-265

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG003776 (538 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2G_00567 Search term: dihydrolipoamide dehydrogenase

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000390667 dihydrolipoamide dehydrogenase [Source:HGNC Symbol;Acc:HGNC:2898] E-value: 1.8e-120 Percent Identity: 49.8
Ensembl 110, assembly GRCh38.p14	ENSP00000205402 dihydrolipoamide dehydrogenase [Source:HGNC Symbol;Acc:HGNC:2898] E-value: 1.8e-120 Percent Identity: 49.8

References