Pseudomonas denitrificans ATCC 13867, H681_01260 (hemC)

Gene Feature Overview

Strain	Pseudomonas denitrificans ATCC 13867 GCF_000349845.1|latest
Locus Tag	H681_01260
Name	hemC
Replicon	chromosome
Genomic location	282488 - 283429 (+ strand)

Cross-References

RefSeq	YP_007655674.1
GI	472323428
EC Number	2.5.1.61
Entrez	14994392
INSDC	AGI22134.1
NCBI Locus Tag	H681_01260
UniParc	UPI0002C4EE61
UniProtKB Acc	M4WQZ5
UniProtKB ID	M4WQZ5_PSEDE
UniRef100	UniRef100_M4WQZ5
UniRef50	UniRef50_Q4K3X3
UniRef90	UniRef90_A6VE37

Product

Feature Type	CDS
Coding Frame	1
Product Name	porphobilinogen deaminase
Synonyms
Evidence for Translation
Charge (pH 7)	-7.70
Kyte-Doolittle Hydrophobicity Value	-0.056
Molecular Weight (kDa)	33683.1
Isoelectric Point (pI)	5.10

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 586 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG004841 (536 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: H681_01260 Search term: hemC Search term: porphobilinogen deaminase

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000497255 hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982] E-value: 6.3e-61 Percent Identity: 42.6
Ensembl 110, assembly GRCh38.p14	ENSP00000376584 hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982] E-value: 6.3e-61 Percent Identity: 42.6
Ensembl 110, assembly GRCh38.p14	ENSP00000498786 hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982] E-value: 6.3e-61 Percent Identity: 42.6
Ensembl 110, assembly GRCh38.p14	ENSP00000444730 hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982] E-value: 6.3e-61 Percent Identity: 42.6

References