Pseudomonas aeruginosa 2192, PA2G_00940

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa 2192
GCF_000152545.1|latest
Locus Tag
PA2G_00940
Name
Replicon chromosome
Genomic location 1016519 - 1017142 (+ strand)

Cross-References

RefSeq ZP_04933618.1
GI 254240296
NCBI Locus Tag PA2G_00940
UniProtKB Acc A3L7X3
UniProtKB ID A3L7X3_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
isochorismatase
Synonyms
Evidence for Translation
Charge (pH 7) -3.89
Kyte-Doolittle Hydrophobicity Value -0.094
Molecular Weight (kDa) 23.2
Isoelectric Point (pI) 5.63

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1NF9 HYDROLASE 12/13/02 Crystal Structure of PhzD protein from Pseudomonas aeruginosa Pseudomonas aeruginosa 1.5 X-RAY DIFFRACTION 100.0
1NF8 HYDROLASE 12/13/02 Crystal structure of PhzD protein active site mutant with substrate Pseudomonas aeruginosa 1.6 X-RAY DIFFRACTION 99.5

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Isochorismic Acid DB02793 DrugBank 5.1.4 Q7DC80 Phenazine biosynthesis protein PhzD 100.0 207 3.6e-116
Formic acid DB01942 DrugBank 5.1.4 Q7DC80 Phenazine biosynthesis protein PhzD 100.0 207 3.6e-116

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001494 (1079 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2G_00940
Search term: isochorismatase

Human Homologs

References

No references are associated with this feature.