Pseudomonas aeruginosa 2192, PA2G_02381

Gene Feature Overview

Strain	Pseudomonas aeruginosa 2192 GCF_000152545.1|latest
Locus Tag	PA2G_02381
Name
Replicon	chromosome
Genomic location	2667150 - 2667893 (- strand)

Cross-References

RefSeq	ZP_04934998.1
GI	254241676
NCBI Locus Tag	PA2G_02381
UniProtKB Acc	A3LB31
UniProtKB ID	A3LB31_PSEAE

Product

Feature Type	CDS
Coding Frame	1
Product Name	3-ketoacyl-ACP reductase
Synonyms
Evidence for Translation
Charge (pH 7)	-0.52
Kyte-Doolittle Hydrophobicity Value	0.176
Molecular Weight (kDa)	25.6
Isoelectric Point (pI)	6.56

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
4BO3	OXIDOREDUCTASE	05/18/13	Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 2-(3-(trifluoromethyl) anilino)pyridine-3-sulfonamide at 2.5A resolution	PSEUDOMONAS AERUGINOSA	2.5	X-RAY DIFFRACTION	100.0
4BO1	OXIDOREDUCTASE	05/18/13	Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(4-chloro-2,5- dimethoxyphenyl)quinoline-8-carboxamide at 2.2A resolution	PSEUDOMONAS AERUGINOSA	2.2	X-RAY DIFFRACTION	100.0
4BO0	OXIDOREDUCTASE	05/17/13	Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-(4-methoxy-1- methylindazol-3-yl)-3-(2-methoxyphenyl)urea at 2.4A resolution	PSEUDOMONAS AERUGINOSA	2.4	X-RAY DIFFRACTION	100.0
4BO6	OXIDOREDUCTASE	05/18/13	Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 2,3-dihydroindol-1-yl-(2- thiophen-3-yl-1,3-thiazol-4-yl)methanone at 2.8A resolution	PSEUDOMONAS AERUGINOSA	2.8	X-RAY DIFFRACTION	100.0
4BO9	OXIDOREDUCTASE	05/18/13	Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 5-(2-(furan-2-ylmethoxy) phenyl)-2-phenyltetrazole at 2.9A resolution	PSEUDOMONAS AERUGINOSA	2.9	X-RAY DIFFRACTION	100.0
4BNY	OXIDOREDUCTASE	05/17/13	Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 4-(2-phenylthieno(3,2-d) pyrimidin-4-yl)morpholine at 1.8A resolution	PSEUDOMONAS AERUGINOSA	1.8	X-RAY DIFFRACTION	100.0
4BO2	OXIDOREDUCTASE	05/18/13	Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-(1-ethylbenzimidazol-2- yl)-3-(2-methoxyphenyl)urea at 1.9A resolution	PSEUDOMONAS AERUGINOSA	1.9	X-RAY DIFFRACTION	100.0
4BO8	OXIDOREDUCTASE	05/18/13	Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-(2-amino-4- phenylimidazol-1-yl)-3-(2-fluorophenyl)urea at 2.7A resolution	PSEUDOMONAS AERUGINOSA	2.7	X-RAY DIFFRACTION	100.0
4BO7	OXIDOREDUCTASE	05/18/13	Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2,3-dihydro-1H-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6A resolution	PSEUDOMONAS AERUGINOSA	2.6	X-RAY DIFFRACTION	100.0
4BNZ	OXIDOREDUCTASE	05/17/13	Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-methyl-N-phenylindole- 3-carboxamide at 2.5A resolution	PSEUDOMONAS AERUGINOSA	2.5	X-RAY DIFFRACTION	100.0

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002615 (536 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2G_02381 Search term: 3-ketoacyl-ACP reductase

Human Homologs

Ensembl 110, assembly GRCh38.p14

ENSP00000303525 carbonyl reductase 4 [Source:HGNC Symbol;Acc:HGNC:25891] E-value: 4.4e-41 Percent Identity: 42.7

References