Strain |
Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest |
Locus Tag |
PALES_08611
|
Name |
ampC
|
Replicon | chromosome |
Genomic location | 940031 - 941224 (- strand) |
RefSeq | YP_002438469 |
GI | 218889605 |
Entrez | 7175766 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
beta-lactamase
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | 4.38 |
Kyte-Doolittle Hydrophobicity Value | -0.284 |
Molecular Weight (kDa) | 43.4 |
Isoelectric Point (pI) | 8.82 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
PDC-3 | PDC-3 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. [PMID:19258272, PMID:33416461] | ARO:3002500 | protein homolog model | Perfect | 807.0 | 100.0 | 3.2.5 |
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
4HEF | HYDROLASE/HYDROLASE INHIBITOR | 10/03/12 | Structure of avibactam bound to Pseudomonas aeruginosa AmpC | Pseudomonas aeruginosa | 1.86 | X-RAY DIFFRACTION | 99.4 |
6S1S | HYDROLASE | 06/19/19 | Crystal structure of AmpC from Pseudomonas aeruginosa in complex with [3-(2-carboxyvinyl)phenyl]boronic acid] inhibitor | Pseudomonas aeruginosa | 1.78 | X-RAY DIFFRACTION | 99.7 |
8SDN | HYDROLASE | 04/07/23 | Crystal structure of PDC-3 Y221H beta-lactamase | Pseudomonas aeruginosa | 2.1 | X-RAY DIFFRACTION | 99.7 |
8SDL | HYDROLASE | 04/07/23 | Crystal structure of PDC-3 beta-lactamase | Pseudomonas aeruginosa | 1.75 | X-RAY DIFFRACTION | 100.0 |
4X68 | HYDROLASE/HYDROLASE INHIBITOR | 12/07/14 | Crystal Structure of OP0595 complexed with AmpC | Pseudomonas aeruginosa | 1.68 | X-RAY DIFFRACTION | 99.7 |
6I30 | HYDROLASE | 11/02/18 | Crystal structure of the AmpC from Pseudomonas aeruginosa with 1C | Pseudomonas aeruginosa | 2.21 | X-RAY DIFFRACTION | 99.7 |
4GZB | HYDROLASE | 09/06/12 | Crystal structure of native AmpC beta-lactamase from Pseudomonas aeruginosa PAO1 | Pseudomonas aeruginosa | 1.79 | X-RAY DIFFRACTION | 99.7 |
4WZ4 | hydrolase/hydrolase inhibitor | 11/18/14 | Crystal structure of P. aeruginosa AmpC | Pseudomonas aeruginosa PAO1 | 1.05 | X-RAY DIFFRACTION | 99.7 |
2WZX | HYDROLASE | 12/03/09 | AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA)IN COMPLEX WITH compound M-02 | PSEUDOMONAS AERUGINOSA | 1.4 | X-RAY DIFFRACTION | 99.7 |
4NK3 | HYDROLASE/HYDROLASE INHIBITOR | 11/12/13 | Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655 | Pseudomonas aeruginosa | 1.9 | X-RAY DIFFRACTION | 99.7 |
4WYY | hydrolase/hydrolase inhibitor | 11/18/14 | Crystal Structure of P. aeruginosa AmpC | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) | 1.28 | X-RAY DIFFRACTION | 99.7 |
6UR3 | ANTIBIOTIC | 10/22/19 | Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors | Pseudomonas aeruginosa | 1.423 | X-RAY DIFFRACTION | 99.7 |
2WZZ | HYDROLASE | 12/03/09 | AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA)IN COMPLEX WITH compound M-03 | PSEUDOMONAS AERUGINOSA | 1.57 | X-RAY DIFFRACTION | 99.7 |
4OOY | hydrolase/hydrolase inhibitor | 02/04/14 | Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance | Pseudomonas aeruginosa | 1.1 | X-RAY DIFFRACTION | 99.7 |
8SDV | HYDROLASE | 04/07/23 | Crystal structure of PDC-3 Y221H beta-lactamase in complex with the boronic acid inhibitor S02030 | Pseudomonas aeruginosa | 1.42 | X-RAY DIFFRACTION | 99.7 |
8SDS | HYDROLASE | 04/07/23 | Crystal structure of PDC-3 Y221H beta-lactamase in complex with the boronic acid inhibitor LP-06 | Pseudomonas aeruginosa | 1.63 | X-RAY DIFFRACTION | 99.7 |
6UQU | ANTIBIOTIC | 10/21/19 | Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors | Pseudomonas aeruginosa | 1.0902 | X-RAY DIFFRACTION | 99.7 |
8SDR | HYDROLASE/HYDROLASE INHIBITOR | 04/07/23 | Crystal structure of PDC-3 beta-lactamase in complex with the boronic acid inhibitor LP-06 | Pseudomonas aeruginosa | 1.35 | X-RAY DIFFRACTION | 100.0 |
6UQS | ANTIBIOTIC | 10/21/19 | Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors | Pseudomonas aeruginosa | 1.37 | X-RAY DIFFRACTION | 99.7 |
3S1Y | Hydrolase/Hydrolase Inhibitor | 05/16/11 | AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) in complex with a beta-lactamase inhibitor | Pseudomonas aeruginosa | 1.4 | X-RAY DIFFRACTION | 99.7 |
3S22 | Hydrolase/Hydrolase Inhibitor | 05/16/11 | AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) in complex with an inhibitor | Pseudomonas aeruginosa | 1.65 | X-RAY DIFFRACTION | 99.7 |
8SDT | HYDROLASE | 04/07/23 | Crystal structure of PDC-3 beta-lactamase in complex with the boronic acid inhibitor S02030 | Pseudomonas aeruginosa | 1.38 | X-RAY DIFFRACTION | 100.0 |
6UQT | ANTIBIOTIC | 10/21/19 | Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors | Pseudomonas aeruginosa | 1.25 | X-RAY DIFFRACTION | 99.7 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 283 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG001588 (493 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PALES_08611
Search term: ampC
Search term: beta-lactamase
|