Pseudomonas aeruginosa LESB58, PALES_09731 (pbpA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest |
| Locus Tag |
PALES_09731
|
| Name |
pbpA
|
| Replicon | chromosome |
| Genomic location | 1052330 - 1054270 (+ strand) |
Cross-References
| RefSeq | YP_002438580 |
| GI | 218889716 |
| Entrez | 7175850 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
penicillin-binding protein 2
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | 5.83 |
| Kyte-Doolittle Hydrophobicity Value | -0.332 |
| Molecular Weight (kDa) | 72.2 |
| Isoelectric Point (pI) | 8.49 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 7KIS | HYDROLASE/Inhibitor/Antibiotic | 10/24/20 | Crystal structure of Pseudomonas aeruginosa PBP2 in complex with WCK 5153 | Pseudomonas aeruginosa | 2.869 | X-RAY DIFFRACTION | 100.0 |
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| Ceftazidime | DB00438 | DrugBank | 5.1.4 | Q9X6V3 | Penicillin-binding protein 2 | 100.0 | 646 | 0.0e+00 |
| Cefepime | DB01413 | DrugBank | 5.1.4 | Q9X6V3 | Penicillin-binding protein 2 | 100.0 | 646 | 0.0e+00 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 575 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG001680 (534 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PALES_09731
Search term: pbpA
Search term: penicillin-binding protein 2
|
Human Homologs
References
No references are associated with this feature.